Hydroxypropyl methylcellulose (HPMC) ni polymer zitandukanye kandi zikoreshwa cyane mubikorwa bitandukanye, bizwiho imiterere yihariye nibisabwa.Uru ruganda rukomoka kuri selile, polymer karemano iboneka murukuta rwibimera.Kugirango usobanukirwe na hydroxypropylmethylcellulose, birakenewe gucengera mumiterere na synthesis yibi bikomoka kuri selile.
Imiterere ya selile:
Cellulose ni karubone nziza igizwe nurunigi rw'umurongo wa β-D-glucose ibice bihujwe na β-1,4-glycosidic.Iminyururu ya glucose ifashwe hamwe na hydrogène kugirango ibe umurongo utomoye.Cellulose nigice cyingenzi cyubaka urukuta rwibimera, rutanga imbaraga nubukomezi bwingirabuzimafatizo.
Ibikomoka kuri Hydroxypropyl Methylcellulose:
Hydroxypropyl methylcellulose ikomatanyirizwa mu guhindura imiti ya selile no kwinjiza hydroxypropyl na methyl mumatsinda nyamukuru ya selile.Umusaruro ubusanzwe urimo intambwe zikurikira:
Igisubizo cya Etherification:
Methylation: Kuvura selile ukoresheje umuti wa alkaline na methyl chloride kugirango winjize amatsinda ya methyl (-CH3) mumatsinda ya hydroxyl (-OH) ya selile.
Hydroxypropylation: Methylated selulose irongera ikora hamwe na okiside ya propylene kugirango yinjize amatsinda ya hydroxypropyl (-CH2CHOHCH3) muburyo bwa selile.Ubu buryo butezimbere amazi kandi bugahindura imiterere ya selile.
kwezwa:
Cellulose yahinduwe noneho isukurwa kugirango ikureho reagent zose zidakozwe, ibicuruzwa cyangwa umwanda.
Kuma no gusya:
Hydroxypropyl methylcellulose isukuwe yumishijwe hanyuma igahinduka ifu nziza yiteguye gukoreshwa muburyo butandukanye.
Ibigize Hydroxypropyl Methylcellulose:
Ibigize hydroxypropyl methylcellulose irangwa nurwego rwo gusimburana, bivuze urwego urwego hydroxypropyl na methyl rusimbuza amatsinda ya hydroxyl mumurongo wa selile.Ibyiciro bitandukanye bya HPMC bifite impamyabumenyi zitandukanye zo gusimburana, bigira ingaruka kubikemuka, ubwiza nibindi bintu.
Imiti ya hydroxypropyl methylcellulose irashobora kugaragazwa nka (C6H7O2 (OH) 3-mn (OCH3) m (OCH2CH (OH) CH3) n) _x, aho m na n byerekana urwego rwo gusimburwa.
m: urwego rwa methylation (amatsinda ya methyl kuri glucose)
n: urugero rwa hydroxypropylation (amatsinda ya hydroxypropyl kuri glucose)
x: umubare wibice bya glucose mumurongo wa selile
Ibiranga na Porogaramu:
Gukemura: HPMC irashobora gushonga amazi, kandi urwego rwo gusimburwa rugira ingaruka kumiterere yabyo.Ikora igisubizo gisobanutse kandi kigaragara mumazi, bigatuma gikwiranye nuburyo butandukanye.
Viscosity: Ubukonje bwibisubizo bya HPMC biterwa nibintu nkuburemere bwa molekile hamwe nintera yo gusimburwa.Uyu mutungo ningirakamaro mubisabwa nka farumasi isaba kugenzurwa neza.
Imiterere ya firime: HPMC irashobora gukora firime yoroheje mugihe igisubizo cyumye, bigatuma igira akamaro mugutwikira imiti, ibiryo nizindi nganda.
Stabilisateur na Thickeners: Mu nganda zibiribwa, HPMC ikoreshwa nkibibyimbye kandi bigahindura ibicuruzwa bitandukanye, birimo isosi, desert, nibicuruzwa bitetse.
Porogaramu ya farumasi: HPMC ikoreshwa cyane muburyo bwo kuvura imiti, harimo ibinini, capsules, hamwe n’ibisubizo by’amaso, bitewe nuburyo bugenzurwa n’ibinyabuzima.
Kubaka no gutwikira: HPMC ikoreshwa mubikoresho byubwubatsi nka minisiteri, ibiti bya tile na plasta.Irakoreshwa kandi mubyimbye na stabilisateur mu gusiga irangi no gutwikira.
Ibicuruzwa byita ku muntu ku giti cye: Mu mavuta yo kwisiga no kwita ku muntu ku giti cye, HPMC iboneka mu bicuruzwa nka cream, amavuta yo kwisiga hamwe na shampo, aho bitanga imiterere n’umutekano.
Hydroxypropyl methylcellulose iboneka na methylation na hydroxypropylation ya selile.Nibikorwa byinshi bya polymer hamwe nurwego runini rwo gukoresha.Imiterere yihariye itanga agaciro mu nganda nka farumasi, ibiryo, ubwubatsi no kwita ku muntu ku giti cye.Guhindura igenzura rya selile irashobora guhuza neza imiterere ya HPMC, ikagira igice cyingenzi cyibicuruzwa byinshi duhura nabyo mubuzima bwacu bwa buri munsi.
Igihe cyo kohereza: Mutarama-10-2024