Hydroxypropyl methylcellulose (HPMC) ni polymer ikoreshwa cyane muri farumasi, kwisiga, ibikomoka ku biribwa, nibindi bikorwa bitandukanye byinganda.Irakoreshwa cyane bitewe na biocompatibilité, idafite uburozi, nubushobozi bwo guhindura imiterere ya rheologiya yibisubizo.Ariko, ni ngombwa kumva uburyo bwo gusesa HPMC neza kugirango ukoreshe imitungo yayo neza.
Amazi: HPMC irashonga cyane mumazi, bigatuma ihitamo kubintu byinshi.Nyamara, igipimo cyo gusesa kirashobora gutandukana bitewe nubushyuhe, pH, n amanota ya HPMC yakoreshejwe.
Umuti ukomoka ku buhinzi: Umuti utandukanye wumunyu ngugu urashobora gushonga HPMC muburyo butandukanye.Bimwe mubisanzwe byangiza umubiri harimo:
Inzoga: Isopropanol (IPA), Ethanol, methanol, nibindi. Iyi alcool ikunze gukoreshwa mumiti yimiti kandi irashobora gushonga HPMC neza.
Acetone: Acetone nigisubizo gikomeye gishobora gushonga HPMC neza.
Ethyl Acetate: Nubundi buryo bwumuti bushobora gushonga HPMC neza.
Chloroform: Chloroform ni umusemburo ukabije kandi ugomba gukoreshwa witonze kubera uburozi bwayo.
Dimethyl Sulfoxide (DMSO): DMSO ni umusemburo wa polar aprotique ushobora gushonga ibintu byinshi, harimo HPMC.
Propylene Glycol (PG): PG ikoreshwa kenshi nka co-solvent mumiti yimiti.Irashobora gushonga HPMC neza kandi ikoreshwa kenshi hamwe namazi cyangwa andi mashanyarazi.
Glycerine: Glycerine, izwi kandi ku izina rya glycerol, ni umusemburo usanzwe mu miti no kwisiga.Bikunze gukoreshwa hamwe namazi yo gushonga HPMC.
Polyethylene Glycol (PEG): PEG ni polymer ifite imbaraga zo gushonga cyane mumazi hamwe na solge nyinshi.Irashobora gukoreshwa mu gusesa HPMC kandi akenshi ikoreshwa muburyo burambye-burekura.
Surfactants: Ibintu bimwe na bimwe bishobora gufasha mu gusesa HPMC mu kugabanya ubukana bw’ubutaka no kunoza amazi.Ingero zirimo Tween 80, sodium lauryl sulfate (SLS), na polysorbate 80.
Acide ikomeye cyangwa Base: Mugihe bidakunze gukoreshwa kubera impungenge z'umutekano no kwangirika kwa HPMC, aside ikomeye (urugero, aside hydrochloric) cyangwa ibishingwe (urugero, hydroxide ya sodium) irashobora gushonga HPMC mugihe gikwiye.Nyamara, imiterere ya pH ikabije irashobora gutuma umuntu yangirika.
Ibikoresho bigoye: Bimwe mubintu bigoye nka cyclodextrins birashobora gukora ibice byinjizwamo hamwe na HPMC, bifasha mukuyisesa no kongera imbaraga zayo.
Ubushyuhe: Mubisanzwe, ubushyuhe bwo hejuru bwongera umuvuduko wa HPMC mumashanyarazi nkamazi.Nyamara, ubushyuhe burenze urugero bushobora gutesha polymer, bityo rero ni ngombwa gukora mubushuhe butekanye.
Imyitozo ya mashini: Gukurura cyangwa kuvanga birashobora koroshya iseswa rya HPMC mukongera umubano hagati ya polymer na solve.
Ingano ya Particle: Ifu nziza cyane HPMC izashonga byoroshye kuruta ibice binini kubera ubuso bwiyongereye.
Ni ngombwa kumenya ko guhitamo ibisubizo no guseswa biterwa na progaramu yihariye hamwe nibintu byifuzwa byibicuruzwa byanyuma.Guhuza nibindi bikoresho, gutekereza kumutekano, hamwe nibisabwa amabwiriza nabyo bigira ingaruka kumahitamo yumuti nuburyo bwo gusesa.Byongeye kandi, ni ngombwa gukora ubushakashatsi bwuzuzanya hamwe nogupima ituze kugirango tumenye neza ko inzira yo gusesa itagira ingaruka mbi kumiterere cyangwa imikorere yibicuruzwa byanyuma.
Igihe cyo kohereza: Werurwe-22-2024