Hydroxypropylmethylcellulose (HPMC), nka polymer hydrophilique ikunze gukoreshwa mu nganda zimiti, ikoreshwa cyane mubitambaro bya tablet, kugenzura ibyasohotse hamwe nubundi buryo bwo gutanga ibiyobyabwenge.Imwe mu miterere yingenzi ya HPMC nubushobozi bwayo bwo kugumana amazi, bigira ingaruka kumikorere yayo nkibikoresho bya farumasi.Muri iki kiganiro, tuzasesengura ibintu byingenzi bigira ingaruka ku gufata amazi ya HPMC, harimo uburemere bwa molekile, ubwoko bwasimbuwe, kwibanda, na pH.
uburemere bwa molekile
Uburemere bwa molekuline ya HPMC bugira uruhare runini mukumenya ubushobozi bwo gufata amazi.Muri rusange, uburemere buke bwa HPMC ni hydrophilique kuruta uburemere buke bwa HPMC kandi irashobora gukuramo amazi menshi.Ni ukubera ko uburemere buke bwa HPMCs bufite iminyururu ndende ishobora gufatana no gukora urusobe runini, byongera amazi ashobora kwinjizwa.Ariko, twakagombye kumenya ko uburemere bukabije bwa HPMC buzatera ibibazo nkubukonje hamwe ningorane zo gutunganya.
ubundi
Ikindi kintu kigira ingaruka kubushobozi bwo gufata amazi ya HPMC nubwoko bwo gusimbuza.HPMC muri rusange iza muburyo bubiri: hydroxypropyl-yasimbuwe na metxy-yasimbuwe.Ubwoko bwa hydroxypropyl bwasimbuwe bufite ubushobozi bwo kwinjiza amazi kurenza ubwoko bwa metxyxy yasimbuwe.Ni ukubera ko hydroxypropyl groupe iri muri molekile ya HPMC ari hydrophilique kandi ikongerera HPMC amazi.Ibinyuranye, ubwoko bwa metxy-yasimbuwe ni hydrophilique nkeya bityo ikaba ifite ubushobozi buke bwo gufata amazi.Kubwibyo, ubundi bwoko bwa HPMC bugomba gutoranywa neza ukurikije imitungo yifuzwa yibicuruzwa byanyuma.
wibande kuri
Ubwinshi bwa HPMC bugira ingaruka no kubushobozi bwo gufata amazi.Mugihe gito, HPMC ntabwo ikora imiterere isa na gel, bityo ubushobozi bwayo bwo gufata amazi ni buke.Mugihe ubunini bwa HPMC bwiyongereye, molekile ya polymer yatangiye kwizirika, ikora imiterere isa na gel.Umuyoboro wa gel ukurura kandi ukagumana amazi, kandi ubushobozi bwo gufata amazi ya HPMC bwiyongera hamwe nibitekerezo.Ariko, twakagombye kumenya ko kwibanda cyane kuri HPMC bizatera ibibazo byo gushiraho nkubukonje hamwe ningorane zo gutunganya.Kubwibyo, kwibumbira hamwe kwa HPMC byakoreshejwe bigomba kunozwa kugirango bigerweho ubushobozi bwo gufata amazi mugihe twirinze ibibazo byavuzwe haruguru.
Agaciro PH
Agaciro pH k'ibidukikije aho HPMC gakoreshwa nabyo bizagira ingaruka kubushobozi bwo gufata amazi.Imiterere ya HPMC ikubiyemo amatsinda ya anionic (-COO-) hamwe na hydrophilique Ethylcellulose (-OH).Iionisation ya -COO- matsinda biterwa na pH, kandi impamyabumenyi ya ionisation yiyongera hamwe na pH.Kubwibyo, HPMC ifite ubushobozi bwo gufata amazi murwego rwo hejuru pH.Kuri pH nkeya, -COO- itsinda ryerekanwe kandi hydrophilique yayo iragabanuka, bigatuma ubushobozi bwo gufata amazi buke.Kubwibyo, ibidukikije pH bigomba gutezimbere kugirango bigere kubushobozi bwo gufata amazi HPMC.
mu gusoza
Mu gusoza, ubushobozi bwo gufata amazi ya HPMC ni ikintu cyingenzi kigira ingaruka ku mikorere yacyo nkibikoresho bya farumasi.Ibintu byingenzi bigira ingaruka kubushobozi bwo gufata amazi ya HPMC harimo uburemere bwa molekile, ubwoko bwo gusimbuza, kwibanda hamwe nagaciro ka pH.Muguhindura witonze ibyo bintu, ubushobozi bwo gufata amazi ya HPMC burashobora gutezimbere kugirango ugere kubintu byifuzwa byibicuruzwa byanyuma.Abashakashatsi mu bya farumasi n’abakora ibicuruzwa bagomba kwitondera cyane kuri ibyo bintu kugirango barebe ko ireme ryiza n’imikorere y’imiti ishingiye kuri HPMC.
Igihe cyo kohereza: Kanama-05-2023