Hydroxypropylmethylcellulose (HPMC) ni polymer itandukanye ikoreshwa cyane mu nganda zitandukanye kubera imiterere yihariye.Uru ruganda rukomoka kuri selile, polymer karemano iboneka murukuta rwibimera.Synthesis ya HPMC ikubiyemo kuvura selile hamwe na okiside ya propylene kugirango itangize amatsinda ya hydroxypropyl hamwe na chloride ya methyl kugirango itangire amatsinda ya methyl.Polimeri yavuyemo yerekana ibintu byinshi byumubiri nu miti, bigatuma ikoreshwa muburyo bwa farumasi, ubwubatsi, ibiryo nizindi nganda.
1.Imiterere yimiterere nibigize:
Hydroxypropyl methylcellulose nigice cya sintetike ya polymer ifite imiterere yimiti igoye.Umugongo wa polymer ugizwe na selile, urunigi rwumurongo wa molekile ya glucose ihujwe na β-1,4-glycosidic.Itsinda rya hydroxypropyl ritangizwa no gusimbuza hydroxyl (-OH) nitsinda rya propyl, naho methyl itsinda ryatangijwe muburyo busa.Urwego rwo gusimbuza (DS) rugereranya impuzandengo ya hydroxypropyl na methyl matsinda ya glucose kandi bigira ingaruka kumashanyarazi, ibishishwa, hamwe nubushyuhe bwa polymer.
2. Gukemura:
Kimwe mu bintu biranga HPMC ni imyitwarire yo gusesa.Irashobora gushonga mumazi akonje kandi ashyushye, itanga inyungu zidasanzwe mubikorwa bitandukanye.Ibisubizo birashobora guhindurwa muguhindura urwego rwo gusimbuza nuburemere bwa molekuline ya polymer.Uyu mutungo utuma HPMC iba umukandida mwiza muri sisitemu yo gutanga imiti igenzurwa-irekurwa, aho igipimo cyo gusesa kigira uruhare runini mu gusohora ibiyobyabwenge.
3. Viscosity:
Hydroxypropyl methylcellulose iraboneka muburyo butandukanye bwijimye, bitewe nibintu nkuburemere bwa molekile, urugero rwo gusimburwa, hamwe nibisubizo byibisubizo.Ubwiza bwibisubizo bya HPMC bubafasha gukoreshwa mubikorwa byinshi byinganda, harimo imiti, nkibibyimbye muburyo bwa dosiye, kandi nkibikoresho byo gukora firime byo gutwikira.
4. Igikorwa cyo gukora film:
Ubushobozi bwo gukora firime ya HPMC nibyingenzi mubikorwa nko gutwikira ibiyobyabwenge, aho bikoreshwa mugutanga urwego rukingira guhisha uburyohe bwibiyobyabwenge, kugenzura ibiyobyabwenge, no kuzamura umutekano.Filime ya HPMC irasobanutse kandi yoroheje, kandi imiterere yabyo irashobora guhuzwa muguhindura polymer yibanze, uburemere bwa molekile nibirimo plastike.
5. Imikorere yubushyuhe:
Hydroxypropyl methylcellulose yerekana ubushyuhe bwiza bwubushyuhe mubushyuhe bwihariye.Imiterere yubushyuhe iterwa nibintu nkurwego rwo gusimbuza, uburemere bwa molekile, no kuba hari plasitike.Iyi miterere ituma HPMC ikwiranye na progaramu aho ihindagurika ryumuriro ari ingenzi, nko gutegura imiti yangiza imiti.
6. Guhuza ibinyabuzima:
Mu rwego rwa farumasi n’ibinyabuzima, biocompatibilité ni ikintu cyingenzi ku bikoresho bikoreshwa muri sisitemu yo gutanga imiti.Hydroxypropyl methylcellulose muri rusange ifatwa nkumutekano kandi ifite biocompatibilité nziza.Ikoreshwa cyane mugutegura impapuro zo munwa, ibisubizo byamaso hamwe na sisitemu yo gutanga imiti igenzurwa.
7. Kubika amazi no kubyimba:
Ubushobozi bwa HPMC bwo kugumana amazi no kongera ibisubizo bituma bugira agaciro mubikoresho byubwubatsi nkibicuruzwa bishingiye kuri sima.Muri iyi porogaramu, HPMC ikora nk'igikoresho cyo kubika amazi, kunoza imikorere no kwirinda gukama hakiri kare ibikoresho.Umubyimba ukoreshwa kandi mubicuruzwa bitandukanye byibiribwa kugirango wongere ubwiza hamwe numunwa.
8. Kugenzura-kurekura ibiyobyabwenge:
Kimwe mubikorwa byingenzi bya hydroxypropyl methylcellulose ni mugutegura uburyo bwo gutanga imiti igenzurwa-irekurwa.Imisemburo ya polymer, ibishishwa, hamwe nogukora firime byorohereza irekurwa ryibiyobyabwenge, bigafasha gutanga imiti ihamye kandi igamije.Ibi ni ingirakamaro cyane mugutezimbere abarwayi no kugabanya ingaruka zijyanye no kurekura ibiyobyabwenge byihuse.
9. Guhagarara munsi ya pH itandukanye:
HPMC yerekana ituze hejuru ya pH yagutse, bigatuma ikwiranye nibisabwa bisaba gutekana mubihe bya acide cyangwa alkaline.Uyu mutungo ufite akamaro muri farumasi kuko imiti ishobora guhura nibidukikije bya pH mubice byigifu.
10. Imiterere ya rheologiya:
Imyitwarire ya rheologiya yibisubizo bya HPMC ningirakamaro mubisabwa aho ibintu bitemba ari ingenzi, nko gutegura ibifuniko, ibifata hamwe na geles.Imiterere ya rheologiya irashobora guhuzwa muguhindura uburemere nuburemere bwa molekuline ya HPMC kugirango igere kubiranga ibintu bisabwa kugirango e-igenzure neza.
Hydroxypropyl methylcellulose yabaye polymer yingirakamaro mu nganda zinyuranye kubera guhuza kwayo kudasanzwe, kwiyegeranya, ubushobozi bwo gukora firime hamwe na biocompatibilité.Ubwinshi bwayo butuma bukoreshwa muburyo butandukanye, uhereye kumiti yimiti nibikoresho byubwubatsi kugeza ibiryo na cosmetike.Mugihe abashakashatsi bakomeje gushakisha uburyo bushya nuburyo bukoreshwa, imiterere ya hydroxypropyl methylcellulose nta gushidikanya ko izagira uruhare mu iterambere mu nzego zitandukanye, ikemeza ko ikomeza akamaro kayo mu bumenyi n’inganda.
Igihe cyo kohereza: Mutarama-10-2024