Gutegura igisubizo cya Hydroxypropyl Methylcellulose (HPMC) nigikorwa cyibanze mu nganda zimiti n’ibiribwa.HPMC ni polymer ikoreshwa muburyo bwo gutwikira bitewe nuburyo bwiza bwo gukora firime, ituze, hamwe no guhuza nibintu bitandukanye bikora.Igisubizo cyo gutwikira gikoreshwa mugutanga ibice birinda, kugenzura imyirondoro irekura, no kunoza isura n'imikorere ya tableti, capsules, nubundi buryo bukomeye bwa dosiye.
1. Ibikoresho bisabwa:
Hydroxypropyl Methylcellulose (HPMC)
Umuti (mubisanzwe amazi cyangwa uruvange rwamazi ninzoga)
Plastiseri (ntibigomba, kunoza imiterere ya firime)
Ibindi byongeweho (bidashoboka, nkibara, amabara, cyangwa imiti igabanya ubukana)
2. Ibikoresho bikenewe:
Kuvanga icyombo cyangwa ibikoresho
Stirrer (ubukanishi cyangwa magnetiki)
Gupima uburimbane
Inkomoko yo gushyushya (niba bikenewe)
Shungura (nibiba ngombwa gukuraho ibibyimba)
metero ya pH (niba ihinduka rya pH ari ngombwa)
Ibikoresho byumutekano (gants, indorerwamo, ikote rya laboratoire)
3. Inzira:
Intambwe ya 1: Gupima Ibigize
Gupima ingano isabwa ya HPMC ukoresheje umunzani wo gupima.Amafaranga arashobora gutandukana bitewe nubushake bwifuzwa bwibisubizo hamwe nubunini bwicyiciro.
Niba ukoresheje plastike cyangwa ibindi byongeweho, bapima ingano isabwa nayo.
Intambwe ya 2: Gutegura igisubizo
Menya ubwoko bwa solvent igomba gukoreshwa ukurikije porogaramu no guhuza nibintu bikora.
Niba ukoresha amazi nkigishishwa, menya neza ko afite isuku ryinshi kandi nibyiza ko yatandukanijwe cyangwa yeguriwe Imana.
Niba ukoresheje imvange y'amazi n'inzoga, menya igipimo gikwiye gishingiye ku gukemuka kwa HPMC n'ibiranga ibyifuzo biranga igisubizo.
Intambwe ya 3: Kuvanga
Shira icyombo kivanga kuri stirrer hanyuma wongereho umusemburo.
Tangira gukurura umusemburo ku muvuduko uringaniye.
Buhoro buhoro ongeramo ifu ya HPMC yapimwe mbere mumashanyarazi kugirango wirinde gukomera.
Komeza kubyutsa kugeza ifu ya HPMC ikwirakwijwe kimwe mumashanyarazi.Iyi nzira irashobora gufata igihe runaka, bitewe nubunini bwa HPMC hamwe nubushobozi bwibikoresho bikurura.
Intambwe ya 4: Gushyushya (niba bikenewe)
Niba HPMC idashonga rwose mubushyuhe bwicyumba, gushyushya byoroheje birashobora gukenerwa.
Shyushya imvange mugihe ukurura kugeza HPMC isenyutse burundu.Witondere kudashyuha, kuko ubushyuhe bukabije bushobora gutesha agaciro HPMC cyangwa ibindi bigize igisubizo.
Intambwe ya 5: Kwiyongera kwa Plastiseri nibindi byongeweho (niba bishoboka)
Niba ukoresheje plastike, ongeraho igisubizo gahoro gahoro mugihe ukurura.
Muri ubwo buryo, ongeraho ikindi kintu cyose wifuza nkibara cyangwa amabara meza muriki cyiciro.
Intambwe ya 6: pH Guhindura (nibiba ngombwa)
Reba pH yumuti utwikiriye ukoresheje metero pH.
Niba pH itari murwego rwifuzwa kubwimpamvu zihamye cyangwa guhuza, uhindure wongeyeho bike bya acide cyangwa ibisubizo byibanze bikwiranye.
Koresha igisubizo neza nyuma yinyongera hanyuma usuzume pH kugeza urwego rwifuzwa rugezeho.
Intambwe 7: Kuvanga Byanyuma no Kwipimisha
Ibigize byose bimaze kongerwamo no kuvangwa neza, komeza ubyuke muminota mike kugirango umenye ubutinganyi.
Kora ibizamini byose byujuje ubuziranenge nko gupima ubukonje cyangwa kugenzura amashusho ku bimenyetso byose byerekana ibintu cyangwa gutandukanya icyiciro.
Niba bikenewe, unyuze igisubizo unyuze mumashanyarazi kugirango ukureho ibibyimba bisigaye cyangwa ibice bitarakemuka.
Intambwe ya 8: Kubika no gupakira
Hindura igisubizo cyateguwe cya HPMC mububiko bukwiye, byaba byiza amacupa yikirahure ya amber cyangwa ibikoresho bya pulasitiki byujuje ubuziranenge.
Shyiramo kontineri hamwe namakuru akenewe nkumubare wicyiciro, itariki yo kwitegura, kwibanda, hamwe nuburyo bwo kubika.
Bika igisubizo ahantu hakonje, humye harinzwe urumuri nubushuhe kugirango ugumane ituze nubuzima bwiza.
4. Inama n'ibitekerezo:
Buri gihe ukurikize imikorere myiza ya laboratoire nubuyobozi bwumutekano mugihe ukoresha imiti nibikoresho.
Komeza kugira isuku no kutabyara mugihe cyo kwitegura kugirango wirinde kwanduza.
Gerageza guhuza igisubizo cya coating igisubizo hamwe na substrate yagenewe (tableti, capsules) mbere yinini nini yo gusaba.
Kora ubushakashatsi butajegajega kugirango usuzume imikorere yigihe kirekire nuburyo bwo kubika igisubizo.
Andika inzira yo gutegura kandi ubike inyandiko zigamije kugenzura ubuziranenge no kubahiriza amabwiriza.
Igihe cyo kohereza: Werurwe-07-2024