Hydroxypropyl methylcellulose (HPMC) ni polymer itandukanye ikoreshwa cyane mu nganda zitandukanye, harimo imiti, amavuta yo kwisiga, ibiryo, nubwubatsi.Ubushobozi bwayo bwo gukora geles, firime, nibisubizo bituma igira agaciro kubikorwa byinshi.Hydrated ya HPMC nintambwe yingenzi mubikorwa byinshi, kuko ituma polymer yerekana imitungo yifuza neza.
1. Gusobanukirwa HPMC:
HPMC ikomoka kuri selile kandi ikomatanyirizwa hamwe no kuvura selile hamwe na okiside ya propylene na methyl chloride.Irangwa n'amazi-yogukoresha hamwe nubushobozi bwo gukora geles ibonerana, ubushyuhe bwisubiraho.Urwego rwa hydroxypropyl hamwe na metoxyl yo gusimbuza bigira ingaruka kumiterere yabyo, harimo gukomera, kwiyegeranya, hamwe nimyitwarire ya gelation.
2. Akamaro ka Hydration:
Hydration ningirakamaro kugirango ufungure imikorere ya HPMC.Iyo HPMC iyobowe, ikurura amazi ikabyimba, biganisha ku gukora igisubizo kibisi cyangwa gel, bitewe nubunini hamwe nibihe.Iyi hydrated leta ituma HPMC ikora imirimo igenewe, nko kubyimba, gell, gukora firime, no gukomeza gusohora ibiyobyabwenge.
3. Uburyo bwo Kuyobora:
Hariho uburyo bwinshi bwo kuyobora HPMC, bitewe nibisabwa nibisubizo byifuzwa:
a.Ikwirakwizwa ry'amazi akonje:
Ubu buryo bukubiyemo gukwirakwiza ifu ya HPMC mumazi akonje mugihe ukurura buhoro.
Gukwirakwiza amazi akonje birahitamo gukumira no kwemeza neza.
Nyuma yo gutatanya, igisubizo kiremewe kwemererwa kurushaho kwiyobora mugihe cyo kwitonda kugirango ugere kubwiza bwifuzwa.
b.Ikwirakwizwa ry'amazi ashyushye:
Muri ubu buryo, ifu ya HPMC ikwirakwizwa mu mazi ashyushye, ubusanzwe ku bushyuhe buri hejuru ya 80 ° C.
Amazi ashyushye yorohereza amazi vuba no gusesa HPMC, bikavamo igisubizo kiboneye.
Ugomba kwitondera kwirinda ubushyuhe bukabije, bushobora gutesha agaciro HPMC cyangwa gutera ibibyimba.
c.Kutabogama:
Porogaramu zimwe zishobora kubangamira ibisubizo bya HPMC hamwe na alkaline nka sodium hydroxide cyangwa potasiyumu hydroxide.
Kutabogama bihindura pH yumuti, bishobora kugira ingaruka kuri viscosity na gelation ya HPMC.
d.Guhana ibisubizo:
HPMC irashobora kandi kuyoborwa no guhanahana ibishishwa, aho ikwirakwizwa mumazi adashobora kuboneka nka Ethanol cyangwa methanol hanyuma igahanahana amazi.
Guhana ibisubizo birashobora kuba ingirakamaro mubisabwa bisaba kugenzura neza hydrated hamwe nubwiza.
e.Imbere-Hydrated:
Imbere-hydrated ikubiyemo gushiramo HPMC mumazi cyangwa umusemburo mbere yo kuyishyira mubikorwa.
Ubu buryo butuma amazi meza kandi arashobora kuba ingirakamaro mugushikira ibisubizo bihamye, cyane cyane mubikorwa bigoye.
4. Ibintu bigira ingaruka kumazi:
Ibintu byinshi bigira ingaruka kumazi ya HPMC:
a.Ingano ya Particle: Ifu ya HPMC yasya neza hydrata byoroshye kuruta uduce duto duto bitewe nubuso bwiyongereye.
b.Ubushyuhe: Ubushyuhe bwo hejuru muri rusange bwihutisha hydratiya ariko birashobora no kugira ingaruka kumyitwarire yimyitwarire ya HPMC.
c.pH: pH yuburyo bwamazi irashobora kugira ingaruka kumiterere ya ionisation ya HPMC hanyuma rero hydrated kinetics hamwe nimiterere ya rheologiya.
d.Kuvanga: Kuvanga neza cyangwa guhagarika umutima ni ingenzi cyane kugirango hydrated imwe hamwe no gukwirakwiza uduce twa HPMC mumashanyarazi.
e.Kwishyira hamwe: Kwibanda kwa HPMC muburyo bwa hydration bigira ingaruka kumyuka, imbaraga za gel, nibindi bintu byumuti cyangwa gel bivamo.
5. Gusaba:
Hydrated HPMC isanga porogaramu zitandukanye mubikorwa bitandukanye:
a.Imiti ya farumasi: Mububiko bwa tablet, kugenzura-kurekura matrices, ibisubizo byamaso, hamwe no guhagarikwa.
b.Ibicuruzwa byibiribwa: Nkumubyimba, stabilisateur, cyangwa umukozi ukora firime mumasosi, imyambarire, ibikomoka kumata, hamwe nibiryo.
c.Amavuta yo kwisiga: Mu mavuta, amavuta yo kwisiga, geles, nibindi bisobanuro byo guhindura viscosity no emulisation.
d.Ibikoresho byubwubatsi: Mubicuruzwa bishingiye kuri sima, ibifata amatafari, hamwe noguhindura kunoza imikorere, kubika amazi, no gufatira hamwe.
6. Kugenzura ubuziranenge:
Hydrated hydrated ya HPMC ningirakamaro kubikorwa byibicuruzwa no guhoraho.Ingamba zo kugenzura ubuziranenge zishobora kubamo:
a.Ingano yubunini bwisesengura: Kwemeza uburinganire bwikwirakwizwa ryibice kugirango hongerwe imbaraga za hydration.
b.Igipimo cya Viscosity: Gukurikirana ibishishwa mugihe cya hydration kugirango ugere kumurongo wifuzwa kubigenewe.
c.Gukurikirana pH: Kugenzura pH yuburyo bwamazi kugirango hongerwe neza kandi birinde kwangirika.
d.Ikizamini cya Microscopique: Kugenzura amashusho yintangarugero munsi ya microscope kugirango hamenyekane ibice bitandukanijwe nubunyangamugayo.
7. Umwanzuro:
Hydration ninzira yibanze mugukoresha imitungo ya HPMC kubikorwa bitandukanye.Gusobanukirwa uburyo, ibintu, hamwe ningamba zo kugenzura ubuziranenge bujyanye na hydration ni ngombwa mugutezimbere imikorere yibicuruzwa no kwemeza guhuza mubikorwa.Mugukoresha hydrata ya HPMC, abashakashatsi nabashinzwe gukora barashobora gufungura ubushobozi bwayo bwose mubikorwa bitandukanye, bigatera udushya no guteza imbere ibicuruzwa.
Igihe cyo kohereza: Werurwe-04-2024