Ubuvanganzo bujyanye n’imbere mu gihugu ndetse no hanze yarwo mu gutegura imiti ya hydroxypropyl methylcellulose (HPMC) mu myaka yashize yarasuzumwe, irasesengurwa kandi iratondekanya, hamwe n’ikoreshwa ryayo mu myiteguro ihamye, imyiteguro y’amazi, imyiteguro irekuwe kandi igenzurwa, imyiteguro ya capsule, gelatine Iheruka Porogaramu mu rwego rwibisobanuro bishya nkibisobanuro bifatika hamwe na bioadhesives.Bitewe no gutandukanya uburemere bwa molekuline ugereranije nubwiza bwa HPMC, ifite ibiranga nogukoresha emulisifike, gufatira hamwe, kubyimba, kwiyegeranya kwiyongera, guhagarika, geli no gukora firime.Ikoreshwa cyane mubitegura imiti kandi izagira uruhare runini mubijyanye no kwitegura.Hamwe n’ubushakashatsi bwimbitse ku miterere yabwo no kunoza ikoranabuhanga ry’imikorere, HPMC izakoreshwa cyane mu bushakashatsi bw’imiterere mishya ya dosiye n’uburyo bushya bwo gutanga ibiyobyabwenge, bityo biteze imbere iterambere ry’imikorere.
hydroxypropyl methylcellulose;imiti ya farumasi;imiti ya farumasi.
Ibicuruzwa bikomoka kuri farumasi ntabwo ari ishingiro ryibintu gusa byo gushinga imiti mbisi, ahubwo bifitanye isano ningorabahizi yuburyo bwo gutegura, ubwiza bwibiyobyabwenge, umutekano, umutekano, igipimo cyo kurekura ibiyobyabwenge, uburyo bwibikorwa, imikorere yubuvuzi, hamwe niterambere rishya Ifishi ya dosiye n'inzira nshya z'ubuyobozi.bifitanye isano ya hafi.Kugaragara kw'ibikoresho bishya bya farumasi akenshi biteza imbere kunoza ireme ryimyiteguro no guteza imbere dosiye nshya.Hydroxypropyl methylcellulose (HPMC) ni kimwe mu bikoresho bikoresha imiti bizwi cyane mu gihugu no hanze yacyo.Bitewe nuburemere butandukanye bwa molekuline nuburemere, ifite imirimo yo kwigana, guhambira, kubyimba, kubyimba, guhagarika, no gufunga.Ibiranga no gukoresha nka coagulation no gukora firime bikoreshwa cyane mubuhanga bwa farumasi.Iyi ngingo irasubiramo cyane cyane ikoreshwa rya hydroxypropyl methylcellulose (HPMC) mubikorwa mumyaka yashize.
1.Ibintu shingiro bya HPMC
Hydroxypropyl methyl selulose (HPMC), formula ya molekile ni C8H15O8- (C10 H18O6) n- C8H15O8, naho misile igereranije ni 86 000. Iki gicuruzwa nikintu cya sintetike igice, kigizwe na methyl hamwe na polyhydroxypropyl ether ya selile.Irashobora kubyazwa umusaruro muburyo bubiri: Imwe ni uko methyl selulose yo mu cyiciro gikwiye ivurwa na NaOH hanyuma igakorwa na oxyde ya propylene munsi yubushyuhe bwinshi n’umuvuduko mwinshi.Igihe cyo kubyitwaramo kigomba kumara igihe gihagije kugirango methyl na hydroxypropyl bibeho umurongo wa ether Ihujwe nimpeta ya anhydroglucose ya selile muburyo bwa selile, kandi irashobora kugera kurwego rwifuzwa;ikindi ni ukuvura ipamba cyangwa fibre fibre hamwe na soda ya caustic, hanyuma ukitwara hamwe na metani ya chlorine metani na okiside ya propylene ikurikiranye, hanyuma ukayinonosora., yajanjaguwe mu ifu nziza kandi imwe cyangwa granules.
Ibara ryibicuruzwa byera kugeza amata yera, nta mpumuro nziza kandi nta buryohe, kandi imiterere ni granular cyangwa fibrous yoroshye-itemba.Iki gicuruzwa kirashobora gushonga mumazi kugirango kibe igisubizo cyiza cyamata yera ya colloidal hamwe nubwiza runaka.Ikibazo cya sol-gel gishobora kubaho bitewe nubushyuhe bwubushyuhe bwumuti hamwe nibitekerezo bimwe.
Bitewe no gutandukanya ibiri muri ibyo bisimburanya byombi muburyo bwa mikorerexy na hydroxypropyl, ubwoko bwibicuruzwa byagaragaye.Mubitekerezo byihariye, ubwoko bwibicuruzwa bitandukanye biranga ibintu byihariye.Ubushyuhe n'ubushyuhe bwa gelasique, kubwibyo bifite imiterere itandukanye kandi irashobora gukoreshwa mubikorwa bitandukanye.Pharmacopoeia yo mu bihugu bitandukanye ifite amabwiriza atandukanye kandi ahagarariwe kuri moderi: Pharmacopoeia yu Burayi ishingiye ku byiciro bitandukanye by’imitsi itandukanye hamwe n’impamyabumenyi zitandukanye zo gusimbuza ibicuruzwa byagurishijwe ku isoko, bigaragazwa n’amanota wongeyeho imibare, kandi igice ni “mPa s ”.Muri Pharmacopoeia yo muri Amerika, imibare 4 yongeweho nyuma yizina rusange kugirango yerekane ibirimo nubwoko bwa buri kintu gisimbuza hydroxypropyl methylcellulose, nka hydroxypropyl methylcellulose 2208. Imibare ibiri yambere yerekana agaciro kagereranijwe kitsinda rya methoxy.Ijanisha, imibare ibiri yanyuma igereranya ijanisha rya hydroxypropyl.
Hydroxypropyl methylcellulose ya Calocan ifite urukurikirane 3, arirwo E serie, F serie na K, buri serie ifite moderi zitandukanye zo guhitamo.E serie ikoreshwa cyane nka firime ya firime, ikoreshwa mugutwikiriye ibinini, ibinini bya tablet bifunze;E, F ikurikiranwa ikoreshwa nka viscosifiseri no kurekura ibintu bidindiza imyiteguro y'amaso, guhagarika ibintu, kubyimbira imyiteguro y'amazi, ibinini hamwe na Binders ya granules;Urutonde rwa K rukoreshwa cyane cyane kurekura inhibitor hamwe na hydrophilique gel matrix ibikoresho byo gutegura buhoro buhoro kandi bigenzurwa.
Inganda zo mu gihugu zirimo Fuzhou No 2 Uruganda rukora imiti, Huzhou ibiryo n’imiti, Ltd, uruganda rukora imiti ya Sichuan Luzhou, uruganda rukora imiti ya Hubei Jinxian No 1, Feicheng Ruitai Fine Chemical Co., Ltd., Shandong Liaocheng Ahua Pharmaceutical Co ., Ltd., ibimera bya Xi'an Huian, nibindi.
2.Ibyiza bya HPMC
HPMC yabaye imwe mu miti ikoreshwa cyane mu bya farumasi mu gihugu ndetse no hanze yacyo, kubera ko HPMC ifite ibyiza abandi baguzi badafite.
2.1 Amazi akonje
Gushonga mumazi akonje munsi ya 40 ℃ cyangwa 70% Ethanol, ahanini ntigishobora gushonga mumazi ashyushye hejuru ya 60 but, ariko irashobora kuza.
2.2
HPMC ni ubwoko bwa selireose idafite ionic, igisubizo cyacyo ntigishobora kwishyurwa ionic kandi ntigikorana numunyu wicyuma cyangwa ibinyabuzima kama ionic, bityo ibindi bicuruzwa ntibabyitwaramo mugihe cyo gukora imyiteguro.
2.3 Guhagarara
Irahagaze neza kuri acide na alkali, kandi irashobora kubikwa igihe kirekire hagati ya pH 3 na 11 nta mpinduka nini ihari.Igisubizo cyamazi ya HPMC gifite anti-mildew kandi kigumana ubwiza bwimitsi mugihe cyo kubika igihe kirekire.Ibikoresho bya farumasi bifashisha HPMC bifite ireme ryiza kuruta abakoresha ibicuruzwa gakondo (nka dextrin, krahisi, nibindi).
2.4 Guhindagurika
Inkomoko zinyuranye zikomoka kuri HPMC zirashobora kuvangwa muburyo butandukanye, kandi ububobere bwayo burashobora guhinduka ukurikije amategeko runaka, kandi bukagira umubano mwiza, bityo igipimo gishobora gutoranywa ukurikije ibikenewe.
2.5 Kutagira imbaraga
HPMC ntabwo yinjizwa cyangwa ngo ihindurwe mu mubiri, kandi ntabwo itanga ubushyuhe, bityo rero ni ibikoresho byiza byo gutegura imiti.2.6 Umutekano Muri rusange bifatwa ko HPMC ari ibintu bidafite uburozi kandi bidatera uburakari, ikigereranyo cyica hagati yimbeba ni 5 g · kg - 1, naho imiti yica imbeba ni 5. 2 g · kg - 1.Igipimo cya buri munsi ntacyo cyangiza umubiri wumuntu.
3.Ikoreshwa rya HPMC mubisobanuro
3.1 Nkibikoresho bya firime nibikoresho byo gukora film
Ukoresheje HPMC nk'ibikoresho bisizwe na firime, ibinini bisize nta nyungu zigaragara bifite mu guhisha uburyohe no kugaragara ugereranije n'ibinini bisanzwe bisize nk'isukari isize isukari, ariko ubukana bwayo, ifiriti, kwinjiza amazi, urugero rwo gusenyuka., gutwikira ibiro kwiyongera nibindi bipimo byiza nibyiza.Urwego ruto-rwinshi rwibicuruzwa bikoreshwa nkibikoresho bifata amazi ya elegitoronike yifashisha ibinini n'ibinini, naho urwego rwo hejuru rwinshi rukoreshwa nkibikoresho byo gutwikisha firime ya sisitemu yo gukemura ibibazo, mubisanzwe kuri 2% kugeza kuri 20 %.
Zhang Jixing n'abandi.yakoresheje uburyo bwo hejuru yuburyo bwiza kugirango ahindure formulaire ya HPMC nka firime ya firime.Dufashe ibikoresho byerekana firime HPMC, ingano ya alcool ya polyvinyl na plasitike polyethylene glycol nkibintu byiperereza, imbaraga zikaze hamwe nubushobozi bwa firime hamwe nubukonje bwibisubizo bya firime nigipimo cyubugenzuzi, nubusabane hagati yubugenzuzi. indangagaciro nibintu byubugenzuzi bisobanurwa nicyitegererezo cyimibare, kandi inzira nziza yo guhitamo irabonetse.Imikoreshereze yacyo ni hydroxypropyl methylcellulose (HPMCE5) 11,88 g, inzoga ya polyvinyl 24,12 g, plasitike polyethylene glycol 13.00 g, hamwe na viscosity yo guhagarika ni mPa · 20, imbaraga zo gukomera no gukomera kwa firime byageze ku ngaruka nziza .Zhang Yuan yateje imbere gahunda yo kwitegura, akoresha HPMC nk'umuhuza wo gusimbuza ibinyamisogwe, maze ahindura ibinini bya Jiahua ahindura ibinini bisizwe na firime kugira ngo arusheho kunoza imyiteguro yabyo, atezimbere hygroscopique, byoroshye gucika, ibinini byoroshye, byanyanyagiye n'ibindi bibazo, kuzamura ibinini bya tablet.Uburyo bwiza bwo gukora neza bwagenwe nubushakashatsi bwa orthogonal, aribwo, kwibumbira hamwe byari 2% HPMC mugisubizo cya Ethanol 70% mugihe cyo gutwikira, naho igihe cyo gukurura mugihe cyo guhunika cyari 15 min.Ibisubizo Ibisate bya firime ya Jiahua byateguwe nuburyo bushya hamwe no kwandikirwa byatejwe imbere cyane muburyo bugaragara, igihe cyo gusenyuka hamwe nubukomezi bwibanze kuruta ibyakozwe muburyo bwambere bwo kwandikirwa, kandi igipimo cyujuje ibisabwa cyibisate bya firime cyatejwe imbere cyane.yageze hejuru ya 95%.Liang Meiyi, Lu Xiaohui, nibindi bakoresheje hydroxypropyl methylcellulose nkibikoresho byo gukora firime kugirango bategure ibinini bya patinae hamwe na tablete ya matrine.bigira ingaruka ku irekurwa ry'ibiyobyabwenge.Huang Yunran yateguye ibinini byitwa Dragon's Blood Colon Positioning Tablets, hanyuma ashyira HPMC kumuti wo gutwikamo igifu, kandi igice kinini cyacyo cyari 5%.Birashobora kugaragara ko HPMC ishobora gukoreshwa cyane muri sisitemu yo gutanga ibiyobyabwenge.
Hydroxypropyl methylcellulose ntabwo ari ibikoresho byiza bya firime gusa, ahubwo birashobora no gukoreshwa nkibikoresho byerekana firime mugutegura film.Wang Tongshun nibindi byashyizwe mubikorwa kugirango yandike ibinyomoro bya zinc hamwe na aminolexanol yo mu kanwa ikomatanya, hamwe nubworoherane, uburinganire, ubworoherane, gukorera mu mucyo wa firime nkibipimo byiperereza, kubona inyandiko nziza ni PVA 6.5 g, HPMC 0.1 g na 6.0 g ya propylene glycol yujuje ibisabwa byo gutinda-kurekura n'umutekano, kandi irashobora gukoreshwa nk'itegurwa rya firime ya compte.
3.2 nkuguhuza no gutandukana
Urwego rwo hasi rwijimye rwibicuruzwa rushobora gukoreshwa nkuguhuza no gutandukanya ibinini, ibinini na granules, kandi urwego rwo hejuru rwinshi rushobora gukoreshwa gusa.Igipimo kiratandukanye nuburyo butandukanye nibisabwa.Mubisanzwe, ibipimo bya binder kubinini byumye byumye ni 5%, naho ibipimo bya binder kubinini bitose ni 2%.
Li Houtao n'abandi berekanye binder ya tinidazole.8% polyvinylpyrrolidone (PVP-K30), sirupe 40%, ibinyamisogwe 10%, hydroxypropyl methylcellulose K4 (HPMCK4M), 50% Ethanol byakozweho iperereza nko guhuza ibinini bya tinidazole.gutegura ibinini bya tinidazole.Impinduka zigaragara za tableti zisanzwe na nyuma yo gutwikirwa zagereranijwe, hanyuma hapimwa igipimo cyo gukomera, gukomera, igihe ntarengwa cyo gusenyuka nigipimo cyo gusesa ibinini bitandukanye byandikirwa.Ibisubizo Ibinini byateguwe na 2.0% hydroxypropyl methylcellulose byari byuzuye, kandi gupima ifiriti yasanze nta nkomyi yo gukata no gufunga inguni, hanyuma nyuma yo gutwikira, imiterere ya tablet yari yuzuye kandi isura yari nziza.Kubwibyo, ibinini bya tinidazole byateguwe hamwe na 2.0% HPMC-K4 na 50% Ethanol nka binders yakoreshejwe.Guan Shihai yize uburyo bwo gutegura ibinini bya Fuganning, asuzuma ibifatika, anagenzura 50% Ethanol, 15% paste ya krahisi, 10% PVP na 50% bya Ethanol hamwe na compression, yoroshye, hamwe na frivite nkibipimo byerekana isuzuma., 5% CMC-Na na 15% HPMC igisubizo (5 mPa s).Ibisubizo Impapuro zateguwe na 50% Ethanol, 15% paste ya krahisi, 10% PVP 50% yumuti wa Ethanol na 5% CMC-Na yari ifite ubuso bworoshye, ariko kwikuramo nabi no gukomera guke, bidashobora guhaza ibikenewe byo gutwikira;15% HPMC igisubizo (5 mPa · s), hejuru yikibaho kiroroshye, ifiriti irujuje ibisabwa, kandi compressible ni nziza, ishobora guhaza ibikenewe.Kubwibyo, HPMC (5 mPa s) yatoranijwe nkibifatika.
3.3 nkumukozi uhagarika
Urwego rwohejuru-rwinshi rwibicuruzwa bikoreshwa nkumukozi uhagarika gutegura gutegura ubwoko bwamazi yo guhagarika.Ifite ingaruka nziza zo guhagarika, biroroshye gusubiramo, ntabwo ifatanye nurukuta, kandi ifite uduce duto twa flocculation.Igipimo gisanzwe ni 0.5% kugeza 1.5%.Indirimbo Tian n'abandi.ikoreshwa cyane mubikoresho bya polymer (hydroxypropyl methylcellulose, sodium carboxymethylcellulose, povidone, gum ya xanthan, methylcellulose, nibindi) nkibikoresho byo guhagarika gutegura racecadotril.guhagarikwa byumye.Binyuze mu kigereranyo cy’imiterere y’ibimera bitandukanye, ibipimo byongera kugaruka, hamwe na rheologiya, viscosity yo guhagarika hamwe na microscopique morphologie byagaragaye, kandi n’iperereza ry’imiti y’ibiyobyabwenge mu bushakashatsi bwihuse naryo ryarakozweho ubushakashatsi.Ibisubizo Guhagarika byumye byateguwe na 2% HPMC nkumukozi uhagarika yari afite inzira yoroshye kandi ituje.
Ugereranije na methyl selulose, hydroxypropyl methyl selulose ifite ibimenyetso biranga igisubizo kiboneye, kandi umubare muto cyane wibintu bya fibrous bidatatanye birahari, HPMC nayo isanzwe ikoreshwa nkumukozi uhagarika imyiteguro yubuvuzi bwamaso.Liu Jie n'abandi.yakoresheje HPMC, hydroxypropyl selulose (HPC), carbomer 940, polyethylene glycol (PEG), sodium hyaluronate (HA) hamwe no guhuza HA / HPMC nkibikoresho byo guhagarika kugirango bategure ibisobanuro bitandukanye Kubihagarika bya Ciclovir ophthalmic, ingano yubunini bwikigereranyo, nubunini bwibice. Byahiswemo nkibipimo byubugenzuzi kugirango bagaragaze umukozi mwiza uhagarika.Ibisubizo byerekana ko ihagarikwa rya acyclovir ophthalmic ryateguwe na 0.05% HA na 0.05% HPMC nkumukozi uhagarika, igipimo cy’imisozi ni 0,998, ingano y’ibice ni kimwe, guhinduranya ni byiza, kandi imyiteguro ihamye Igitsina cyiyongera.
3.4 Nkumuzitira, gahoro kandi ugenzurwa numukozi wo kurekura hamwe nuwashizeho pore
Urwego rwohejuru rwinshi rwibicuruzwa rukoreshwa mugutegura hydrophilique gel matrix ikomeza-kurekura ibinini, ibibuza hamwe nogukurikirana-kurekura ibintu bivangwa na materique ivanze-ibinini bisohora, kandi bifite ingaruka zo gutinda kurekura ibiyobyabwenge.Ubwinshi bwayo ni 10% kugeza 80%.Amanota-viscosity amanota akoreshwa nka porogène yo gukomeza-kurekura cyangwa kugenzurwa-kurekura.Igipimo cyambere gisabwa kugirango ingaruka zokuvura ibinini zishobora kugerwaho byihuse, hanyuma hagashyirwaho ingaruka zihoraho-kurekura cyangwa kugenzurwa-kurekura, kandi ibiyobyabwenge bikomeza kumaraso bikaguma mumubiri..Hydroxypropyl methylcellulose ihindurwamo gukora geli iyo ihuye namazi.Uburyo bwo kurekura ibiyobyabwenge muri tablet ya matrix bikubiyemo cyane cyane ikwirakwizwa rya gel hamwe nisuri ya gel.Jung Bo Shim nabandi bateguye carvedilol ikomeza-kurekura ibinini hamwe na HPMC nkibikoresho byo kurekura.
Hydroxypropyl methylcellulose nayo ikoreshwa cyane mubinini bya matrix bikomeza-gusohora imiti gakondo yubushinwa, kandi ibyinshi mubikoresho bikora, ibice bifatika hamwe nogutegura imiti yubuvuzi gakondo bwubushinwa.Liu Wen n'abandi.yakoresheje 15% hydroxypropyl methylcellulose nkibikoresho bya matrix, 1% lactose na 5% ya microcrystalline selile yuzuza, hanyuma ategura Jingfang Taohe Chengqi Decoction mumyanya yo mu kanwa ikomeza kurekura.Icyitegererezo ni ikigereranyo cya Higuchi.Sisitemu yo guhimba formula iroroshye, gutegura biroroshye, kandi amakuru yo gusohora arahagaze neza, yujuje ibisabwa na Pharmacopoeia yubushinwa.Tang Guanguang n'abandi.yakoresheje saponine yuzuye ya Astragalus nk'umuti w'icyitegererezo, ategura ibinini bya matrix ya HPMC, anashakisha ibintu bigira ingaruka ku irekurwa ry'ibiyobyabwenge bivuye mu bice bifatika by'ubuvuzi gakondo bw'Abashinwa mu bisate bya HPMC.Ibisubizo Mugihe urugero rwa HPMC rwiyongereye, irekurwa rya astragaloside ryaragabanutse, kandi ijanisha ryo kurekura ibiyobyabwenge ryari rifitanye isano n’umurongo ugereranije n’iseswa rya matrix.Muri tableti ya hypromellose HPMC, hari isano runaka hagati yo kurekura igice cyiza cyubuvuzi gakondo bwabashinwa hamwe na dosiye nubwoko bwa HPMC, kandi inzira yo kurekura hydrophilique chimique monomer isa nayo.Hydroxypropyl methylcellulose ntabwo ibereye gusa hydrophilique, ariko nanone kubintu bitari hydrophilique.Liu Guihua yakoresheje 17% hydroxypropyl methylcellulose (HPMCK15M) nk'ibikoresho bya matrix bikomeza-kurekura, maze ategura ibinini bya Tianshan Xuelian bikomeza kurekura matrise hakoreshejwe uburyo bwo guhunika no gukoresha ibinini.Ingaruka ihamye-kurekura yagaragaye, kandi inzira yo kwitegura yari ihamye kandi birashoboka.
Hydroxypropyl methylcellulose ntabwo ikoreshwa gusa kubinini bya matrix bikomeza kurekurwa byibikoresho bikora nibice bifatika byubuvuzi gakondo bwabashinwa, ariko kandi bikoreshwa cyane mugutegura imiti gakondo yubushinwa.Wu Huichao n'abandi.yakoresheje 20% hydroxypropyl methyl selulose (HPMCK4M) nkibikoresho bya matrix, kandi yakoresheje uburyo bwo guhunika ifu itaziguye kugirango ategure ibinini bya Yizhi hydrophilic gel matrix bishobora kurekura ibiyobyabwenge ubudahwema kandi bihamye mumasaha 12.Saponin Rg1, ginsenoside Rb1 na Panax notoginseng saponin R1 yakoreshejwe nk'ibipimo byo gusuzuma kugira ngo hakorwe iperereza ku irekurwa rya vitro, kandi hashyizweho ibipimo byo kurekura ibiyobyabwenge kugira ngo bige uburyo bwo kurekura ibiyobyabwenge.Ibisubizo Uburyo bwo kurekura ibiyobyabwenge bwahujwe na zero-gahunda ya kinetic ingana hamwe na Ritger-Peppas, aho geniposide yarekuwe no gukwirakwizwa kwa Fick, kandi ibice bitatu muri Panax notoginseng byarekuwe nisuri ya skeletale.
3.5 Gukingira kole nkibibyimbye na colloid
Iyo ibicuruzwa bikoreshejwe nkibibyimbye, ibisanzwe ijanisha ryibanze ni 0.45% kugeza 1.0%.Irashobora kandi kongera ituze rya hydrophobique glue, ikora colloide ikingira, ikarinda ibice guhurira hamwe no guhuriza hamwe, bityo bikabuza gushinga imyanda.Ijanisha rusange ryayo ni 0.5% kugeza 1.5%.
Wang Zhen n'abandi.yakoresheje uburyo bwa L9 orthogonal igerageza uburyo bwo gukora iperereza kubikorwa byo gutegura imiti ikora karubone.Uburyo bwiza bwo gukora kugirango hamenyekane burundu imiti ya karubone ikora ni ugukoresha 0,5% sodium carboxymethyl selulose na 2.0% hydroxypropyl methylcellulose (HPMC irimo 23.0% ya methoxyl, hydroxypropoxyl Base 11,6%) nkibibyimbye, uburyo bwibikorwa bifasha kuzamura iterambere ituze rya karubone ikora imiti.Zhang Zhiqiang n'abandi.yateje imbere pH yunvikana na levofloxacin hydrochloride ophthalmic yiteguye-gukoresha-gel hamwe ningaruka irekura-irekura, ikoresheje karbopol nka materix ya gel na hydroxypropyl methylcellulose nkibikoresho byiyongera.Uburyo bwiza bwo kwifashisha mubigeragezo, amaherezo bubona imiti myiza ni levofloxacin hydrochloride 0.1 g, karbopol (9400) 3 g, hydroxypropyl methylcellulose (E50 LV) 20 g, disodium hydrogen fosifate 0,35 g, aside fosifori 0,45 g ya sodium dihydrogen, 0,50 g ya sodium chloride , 0,03 g ya Ethyl paraben, n'amazi yongewemo gukora 100 mL.Mu kizamini, umwanditsi yerekanye hydroxypropyl methylcellulose METHOCEL yuruhererekane rwisosiyete ya Colorcon ifite ibisobanuro bitandukanye (K4M, E4M, E15 LV, E50LV) kugirango ategure umubyimba ufite ibitekerezo bitandukanye, kandi ibisubizo byatoranije HPMC E50 LV kubyimbye.Thickener kuri pH-yunvikana levofloxacin hydrochloride geles ako kanya.
3.6 nkibikoresho bya capsule
Mubisanzwe, capsule shell material ya capsules ahanini ni gelatine.Igikorwa cyo gukora igikonoshwa cya capsule kiroroshye, ariko haribibazo bimwe na bimwe nko kurinda nabi ubushuhe n’ibiyobyabwenge byangiza ogisijeni, kugabanya ibiyobyabwenge, no gutinda gusenyuka kwa capsule mugihe cyo kubika.Kubwibyo, hydroxypropyl methylcellulose ikoreshwa nkigisimbuza gelatine capsules yo gutegura capsules, itezimbere imikorere ya capsule ningaruka zikoreshwa, kandi yazamuwe cyane mugihugu ndetse no mumahanga.
Gukoresha theophylline nkibiyobyabwenge bigenzura, Podczeck nibindi.yasanze igipimo cyo gusesa ibiyobyabwenge bya capsules hamwe na hydroxypropyl methylcellulose ibishishwa byari byinshi kuruta ibya gelatine capsules.Impamvu yo gusesengura nuko isenyuka rya HPMC ari ugusenyuka kwa capsule yose icyarimwe, mugihe gusenyuka kwa gelatin capsule ari ugusenya imiterere y'urusobe mbere, hanyuma ugasenyuka kwa capsule yose, bityo rero HPMC capsule irakwiriye cyane kuri capsule ibishishwa kugirango uhite usohora.Chiwele n'abandi.yabonye kandi imyanzuro isa kandi igereranya iseswa rya gelatine, gelatine / polyethylene glycol na shell ya HPMC.Ibisubizo byerekanaga ko ibishishwa bya HPMC byashonga vuba mubihe bitandukanye bya pH, mugihe gelatine capsules Yibasiwe cyane nubuzima bwa pH butandukanye.Tang Yue n'abandi.Yerekanye ubwoko bushya bwa capsule shell ya dose-ibiyobyabwenge bitarimo ifu yumye ya sisitemu yo gutwara.Ugereranije na capsule shell ya hydroxypropyl methylcellulose hamwe na capsule shell ya gelatin, iperereza ryumutwe wa capsule hamwe nimiterere yifu yifu mugikonoshwa mubihe bitandukanye byakorewe iperereza, hanakorwa ikizamini cyo gucana.Ibisubizo byerekana ko ugereranije na capatula ya gelatine, ibishishwa bya capsule ya HPMC nibyiza mugutekana no kurinda ifu, bifite imbaraga zo guhangana nubushuhe, kandi bifite ifiriti nkeya ugereranije na gelatin capsule, bityo rero ibishishwa bya HPMC bikwiranye na Capsules yo guhumeka ifu yumye.
3.7 nka bioadhesive
Tekinoroji ya Bioadhesion ikoresha ibicuruzwa hamwe na bioadhesive polymers.Mugukurikiza mucosa yibinyabuzima, byongera ubudahwema nubukomezi bwumubano hagati yimyiteguro na mucosa, kuburyo imiti irekurwa buhoro buhoro kandi ikinjizwa na mucosa kugirango igere ku ntego yo kuvura.Irakoreshwa cyane muri iki gihe.Kuvura indwara zifata igifu, igituba, mucosa yo mu kanwa nibindi bice.
Ikoranabuhanga rya Gastrointestinal bioadhesion ni uburyo bushya bwo gutanga imiti bwakozwe mu myaka yashize.Ntabwo yongerera igihe cyo gutura gusa imyiteguro y’ibiyobyabwenge mu nzira ya gastrointestinal, ahubwo inatezimbere imikorere yimikoranire hagati yibiyobyabwenge na selile ya selile aho ikurura, ihindura amazi ya membrane selile, kandi ituma kwinjiza ibiyobyabwenge muri uturemangingo duto two mu mara twiyongera cyane, bityo bikazamura bioavailable yibiyobyabwenge.Wei Keda n'abandi.Yerekanye ibinini byandikirwa hamwe na dosiye ya HPMCK4M na Carbomer 940 nkibintu byiperereza, kandi akoresha igikoresho cyakozwe na bioadhesion yapimye imbaraga zo gukuramo hagati ya tablet na biofilm yigana nubwiza bwamazi mumifuka ya plastiki., hanyuma amaherezo yahisemo ibikubiye muri HPMCK40 na karbomer 940 kugirango bibe 15 na 27.5 mg mugace keza keza ka NCaEBT yibikoresho bya tablet, muburyo bwo gutegura ibice bya tablet ya NCaEBT, byerekana ko ibikoresho bioadhesive (nka hydroxypropyl methylcellulose) bishobora kugabanya cyane Impinduka gufatira hamwe kwitegura kumubiri.
Imyiteguro ya bioadhesive yo munwa nayo ni ubwoko bushya bwa sisitemu yo gutanga ibiyobyabwenge byizwe cyane mumyaka yashize.Imyiteguro ya bioadhesive yo mu kanwa irashobora gukomera ku biyobyabwenge igice cyanduye cyo mu kanwa k’umunwa, kikaba kitongerera igihe cyo gutura imiti mu mucyo wo mu kanwa, ariko kandi ikarinda mucosa yo mu kanwa.Ingaruka nziza yo kuvura no kunoza ibiyobyabwenge bioavailable.Xue Xiaoyan n'abandi.yahinduye uburyo bwo gukora insuline zo mu kanwa zifata insuline, ukoresheje pome ya pome, chitosan, karbomer 934P, hydroxypropyl methylcellulose (HPMC K392) na sodium alginate nkibikoresho bioadhesive, hamwe no gukonjesha-gukama kugirango utegure insuline yo mu kanwa.Urupapuro rwometseho kabiri.Ibinini byateguwe na insuline byo mu kanwa bifite ibinini bisa na sponge, bifasha kurekura insuline, kandi bifite hydrophobique irinda hydrophobique, ishobora gutuma ibiyobyabwenge birekurwa kandi bikirinda gutakaza ibiyobyabwenge.Hao Jifu n'abandi.yateguye kandi amasaro yubururu-umuhondo umunwa bioadhesive yamashanyarazi ukoresheje Baiji glue, HPMC na carbomer nkibikoresho bioadhesive.
Muri sisitemu yo gutanga ibiyobyabwenge ibyara, tekinoroji ya bioadhesion nayo yakoreshejwe cyane.Zhu Yuting n'abandi.yakoresheje carbomer (CP) na HPMC nkibikoresho bifata hamwe na matrix irekura-irekura kugirango itegure ibinini bya clotrimazole bioadhesive ibyara ibyara hamwe nibipimo bitandukanye, hanyuma bapima ibifatika, igihe cyo gufatira hamwe nijanisha ryibibyimba mubidukikije byamazi yubukorikori., urupapuro rwabigenewe rwerekanwe nka CP-HPMC1: 1, urupapuro rwateguwe rwometseho rufite imikorere myiza yo gufatira hamwe, kandi inzira yari yoroshye kandi birashoboka.
3.8 nka gel yibanze
Nukwitegura gufatana, gel ifite urukurikirane rwibyiza nkumutekano, ubwiza, isuku yoroshye, igiciro gito, inzira yoroshye yo gutegura, hamwe no guhuza neza nibiyobyabwenge.Icyerekezo cy'iterambere.Kurugero, transdermal gel nuburyo bushya bwa dosiye yizwe cyane mumyaka yashize.Ntishobora kwirinda gusa kwangiza ibiyobyabwenge mu nzira ya gastrointestinal no kugabanya ihinduka ry’imisemburo y’imiti y’amaraso, ariko kandi ryabaye imwe muri gahunda nziza yo kurekura ibiyobyabwenge kugira ngo tuneshe ingaruka mbi z’ibiyobyabwenge..
Zhu Jingjie n'abandi.yize ku ngaruka za matrices zitandukanye ku irekurwa rya scutellarin alcool plastid gel muri vitro, hanyuma isuzumwa na karbomer (980NF) na hydroxypropyl methylcellulose (HPMCK15M) nka matrices ya gel, hanyuma ibona scutellarin ikwiranye na scutellarin.Gel matrix ya alcool.Ibisubizo byubushakashatsi byerekana ko 1. 0% carbomer, 1. 5% carbomer, 1. 0% carbomer + 1. 0% HPMC, 1. 5% carbomer + 1. 0% HPMC nka gel matrix Byombi bikwiranye na plastide ya scutellarin .Mu bushakashatsi, byagaragaye ko HPMC ishobora guhindura uburyo bwo kurekura ibiyobyabwenge bya materix ya carbomer gel ihuza na kinetic yo kugereranya ibiyobyabwenge, naho 1.0% HPMC ishobora kuzamura matrike ya 1.0% na matrike ya 1.5%.Impamvu irashobora kuba nuko HPMC yaguka byihuse, kandi kwaguka byihuse mugice cyambere cyubushakashatsi bituma icyuho cya molekuline cyibikoresho bya karbomer kinini, bityo bikihutisha umuvuduko w’ibiyobyabwenge.Zhao Wencui n'abandi.yakoresheje carbomer-934 na hydroxypropyl methylcellulose nk'abatwara gutegura gelfloxacin ophthalmic gel.Igikorwa cyo kwitegura kiroroshye kandi kirashoboka, kandi ubuziranenge bujyanye na gele y'amaso ya “Pharmacopoeia yo mu Bushinwa” (2010 Edition) Ibisabwa ubuziranenge.
3.9 Imiti igabanya ubukana bwa sisitemu yo kwikorera mikorobe
Sisitemu yo gutanga imiti yonyine (SMEDDS) ni ubwoko bushya bwa sisitemu yo gutanga imiti yo mu kanwa, ikaba ari imvange imwe, itajegajega kandi ikorera mu mucyo igizwe n'ibiyobyabwenge, icyiciro cya peteroli, emulifier na co-emulsifier.Ibigize ibyanditswe biroroshye, kandi umutekano numutekano nibyiza.Ku miti idashonga neza, ibikoresho bya fibre polymer fibre polymer, nka HPMC, polyvinylpyrrolidone (PVP), nibindi, byongerwaho kenshi kugirango ibiyobyabwenge byubusa kandi ibiyobyabwenge bikubiye muri microemuliyoni bigera kumeneka birenze urugero mumyanya yigifu, kugirango bigere kongera imiti igabanya ubukana no kunoza bioavailability.
Peng Xuan n'abandi.yateguye silibinin supersaturated self-emulising sisitemu yo gutanga ibiyobyabwenge (S-SEDDS).Oxyethylene hydrogenated amavuta ya castor (Cremophor RH40), 12% caprylic capric aside polyethylene glycol glyceride (Labrasol) nka emulifisiferi, na 50 mg · g-1 HPMC.Kwiyongera kuri HPMC muri SSEDDS birashobora kurenza silibinine yubusa gushonga muri S-SEDDS kandi ikabuza silibinin kugwa.Ugereranije na gakondo yo kwikorera mikorobe, umubare munini wa surfactant wongeyeho kugirango wirinde ibiyobyabwenge bituzuye.Kwiyongera kwa HPMC birashobora gutuma imbaraga za silibinine zishira mugihe cyo gusesa ugereranije, bikagabanya emulisiyonike yo kwikorera mikorobe.ingano yumukozi.
4.Umwanzuro
Birashobora kugaragara ko HPMC yakoreshejwe cyane mumyiteguro kubera imiterere yumubiri, iyimiti n’ibinyabuzima, ariko HPMC nayo ifite ibitagenda neza mumyiteguro, nkibintu byo kurekurwa mbere na nyuma yo guturika.methyl methacrylate) kugirango atezimbere.Muri icyo gihe, abashakashatsi bamwe bakoze ubushakashatsi ku ikoreshwa ry’imyumvire ya osmotic muri HPMC bategura ibinini bya karbamazepine bikomeza kurekurwa hamwe na hydrochloride ya verapamil ikomeza kurekura kugira ngo barusheho kwiga uburyo bwo kurekura.Mu ijambo, abashakashatsi benshi kandi benshi barimo gukora imirimo myinshi kugirango ishyirwa mu bikorwa rya HPMC mu myiteguro, kandi hamwe n’ubushakashatsi bwimbitse bw’imiterere yabwo ndetse no kunoza ikoranabuhanga ryitegura, HPMC izakoreshwa cyane muburyo bushya bwa dosiye. na dosiye nshya.Mubushakashatsi bwa sisitemu yimiti, hanyuma utezimbere iterambere rihoraho rya farumasi.
Igihe cyo kohereza: Ukwakira-08-2022