Uburyo bwa alkali bwo gutanga umusaruro wa hydroxypropyl methylcellulose (HPMC)

Hydroxypropyl methylcellulose (HPMC) nigikoresho cyingenzi gifite uburyo bwinshi bukoreshwa mubikorwa bya farumasi kimwe nizindi nganda nkibiryo, amavuta yo kwisiga nubwubatsi.Isabwa rya HPMC ryagiye ryiyongera uko imyaka yagiye ihita bitewe n’imiterere yihariye nko kubyimba, guhuza, gukora firime no kubika amazi.Muri iki kiganiro, tuzaganira ku buryo bwo kubyara alkaline uburyo bwo gukora hydroxypropyl methylcellulose (HPMC).

Uburyo bwo kubyara alkali uburyo bwa hydroxypropyl methylcellulose (HPMC) ni inzira selile ikora na oxyde ya propylene na methyl chloride imbere ya alkali.Inzira ibaho munsi yubushyuhe, umuvuduko nigihe cyagenwe kugirango bitange ibicuruzwa byiza bya HPMC.

Intambwe yambere yo kubyara HPMC ukoresheje uburyo bwo gukora alkaline yogukoresha ni ugutegura ibikoresho fatizo bya selile.Cellulose ibanza kwezwa ikuraho umwanda uwo ariwo wose hanyuma igahinduka selile ya alkali ikoresheje alkali nka hydroxide ya sodium.Iyi ntambwe irakomeye kuko yongera reaction ya selile hamwe na reagent zikoreshwa mubyiciro bikurikira.

Alkali selulose ivurwa hamwe nuruvange rwa oxyde ya propylene na methyl chloride munsi yubushyuhe nigitutu.Imyitwarire hagati ya alkali selulose na reagent itera gukora ibicuruzwa, bikaba bivanze na hydroxypropyl methylcellulose nibindi bicuruzwa.

Uruvange rwogejwe, rutabogamye kandi rwungururwa kugirango rukureho umwanda nka reagent zidakozwe hamwe nibicuruzwa.Igisubizo cyavuyeho noneho cyibanda kumyuka kugirango ubone ibicuruzwa byiza bya HPMC.

Uburyo bwa alkali bwo kubyaza umusaruro hydroxypropyl methylcellulose (HPMC) bufite ibyiza byinshi ugereranije nubundi buryo bwo gukora nka etherification.Kimwe mu byiza ni uko ari inzira yangiza ibidukikije.Bitandukanye nubundi buryo, uburyo bwo gutanga umusaruro wa alkali ntabwo bukoresha umusemburo wa halogene wangiza ibidukikije nubuzima bwabantu.

Iyindi nyungu yubu buryo ni umusaruro wibicuruzwa byiza bya HPMC.Kugenzura uko ibintu byifashe byemeza ko ibicuruzwa byanyuma bifite ireme kandi bikwiranye na porogaramu zitandukanye.

Gukoresha HPMC mu nganda zimiti ningirakamaro mugukora ibinini, capsules nubundi buryo bwa dosiye.HPMC irashobora gukoreshwa nka binder, disintegrant, coating agent, nibindi. Gukoresha HPMC muribi bikorwa byemeza ko ifishi ya dosiye yujuje ubuziranenge kandi yujuje ubuziranenge busabwa.

HPMC ikoreshwa kandi mubyimbye, emulifier na stabilisateur mu nganda zibiribwa.Imikoreshereze ya HPMC mubicuruzwa byibiribwa itanga imiterere ihamye, ubwiza nubwiza.

Mu nganda zubaka, HPMC ikoreshwa nkinyongera ya sima kugirango itezimbere imikorere, gufata amazi hamwe nuburinganire bwa sima.Imikoreshereze ya HPMC yemeza ko ibicuruzwa byubwubatsi bifite ireme kandi byujuje ubuziranenge busabwa.

Muri make, uburyo bwo gukora alkali bwo gutunganya hydroxypropyl methylcellulose (HPMC) ninzira yo gukora ibicuruzwa byiza bya HPMC kandi bikoreshwa cyane mubikorwa bitandukanye nka farumasi, ibiryo, nubwubatsi.Imikoreshereze ya HPMC muriyi porogaramu iremeza ko ibicuruzwa bifite ubuziranenge kandi byujuje ubuziranenge busabwa.Ubu buryo bwo kubyaza umusaruro nabwo bwangiza ibidukikije kandi butanga ibicuruzwa byiza bya HPMC.