Kugirango tugereranye CMC (carboxymethylcellulose) na HPMC (hydroxypropylmethylcellulose), dukeneye gusobanukirwa imitungo yabo, imikoreshereze, ibyiza, ibibi, nibishobora gukoreshwa. Ibikomoka kuri selile byombi bikoreshwa cyane mu nganda zitandukanye, harimo imiti, ibiryo, amavuta yo kwisiga no kubaka. Buriwese ufite imitungo yihariye ituma ikwiranye nintego zitandukanye. Reka dukore igereranya ryimbitse kugirango turebe imwe nziza mubihe bitandukanye.
1. Ibisobanuro n'imiterere:
CMC. Irimo amatsinda ya carboxymethyl (-CH2-COOH) ahujwe na amwe mumatsinda ya hydroxyl ya monomers ya glucopyranose agize umugongo wa selile.
HPMC (hydroxypropyl methylcellulose): HPMC kandi ikomoka ku mazi ya elegitoronike ya selile ikomoka mu kuvura selile hamwe na okiside ya propylene na methyl chloride. Irimo hydroxypropyl hamwe na matsinda ya mikorobe ifatanye na selile ya rugongo.
2. Gukemura:
CMC: Kubora cyane mumazi, bikora igisubizo kiboneye, kibonerana. Yerekana imyitwarire yimyitwarire ya pseudoplastique, bivuze ko ububobere bwayo bugabanuka mugihe cyo guhangayika.
HPMC: Nanone gushonga mumazi, bigakora igisubizo kiboneka neza kuruta CMC. Irerekana kandi imyitwarire ya pseudoplastique.
3.Imiterere ya Reologiya:
CMC: Yerekana imyitwarire yogosha, bivuze ko ububobere bwayo bugabanuka hamwe no kongera umuvuduko wogosha. Uyu mutungo utuma bikenerwa mubisabwa aho bisabwa kubyimbye ariko igisubizo kigomba gutemba byoroshye munsi yintama, nkamabara, ibikoresho byo kwisiga hamwe na farumasi.
HPMC: yerekana imyitwarire isa na CMC, ariko ububobere bwayo buri hejuru murwego rwo hasi. Ifite imiterere myiza yo gukora firime, ituma ikoreshwa mubisabwa nka coatings, ibifatika hamwe na farumasi igenzurwa.
4. Guhagarara:
CMC: Mubisanzwe bihamye kurwego runini rwa pH nubushyuhe. Irashobora kwihanganira urwego ruciriritse rwa electrolytike.
HPMC: Ihamye kuruta CMC mubihe bya acide, ariko irashobora kwandura hydrolysis mugihe cya alkaline. Irumva kandi ibice bisa, bishobora gutera gelation cyangwa imvura.
5. Gusaba:
CMC: ikoreshwa cyane nkibibyimbye, stabilisateur hamwe nogukoresha amazi mu biribwa (nka ice cream, isosi), imiti (nka tableti, guhagarikwa) hamwe no kwisiga (nka cream, amavuta yo kwisiga).
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6. Uburozi n'umutekano:
CMC: Mubisanzwe bizwi ko bifite umutekano (GRAS) ninzego zishinzwe kugenzura iyo bikoreshejwe mugihe cyagenwe mubiribwa na farumasi. Nibinyabuzima bishobora kwangirika kandi ntabwo ari uburozi.
HPMC: Na none ifatwa nkumutekano mukoresha mugihe cyagenwe. Nibinyabuzima bihuza kandi bikoreshwa cyane murwego rwa farumasi nkumukozi urekura hamwe na tablet binder.
7. Igiciro no Kuboneka:
CMC: Mubisanzwe birahenze kuruta HPMC. Iraboneka byoroshye kubatanga ibintu bitandukanye kwisi.
HPMC: Birahenze cyane bitewe nuburyo bwo kuyibyaza umusaruro kandi rimwe na rimwe bitangwa nabaguzi bamwe.
8. Ingaruka ku bidukikije:
CMC: Biodegradable, ikomoka kubikoresho bishobora kuvugururwa (selile). Bifatwa nkibidukikije.
HPMC: Na biodegradable kandi ikomoka kuri selile, bityo rero ikangiza ibidukikije cyane.
Byombi CMC na HPMC bifite imitungo yihariye ituma byongerwaho agaciro mubikorwa byinshi. Guhitamo hagati yabo biterwa nibisabwa byihariye bisabwa nko kwikemurira ibibazo, kwiyegeranya, gutuza no gutekereza kubiciro. Muri rusange, CMC irashobora gukundwa bitewe nigiciro cyayo gito, ihindagurika ryinshi rya pH, hamwe nuburyo bukwiye bwo kurya no kwisiga. Ku rundi ruhande, HPMC, irashobora gutoneshwa kubera ubwiza bwayo bwinshi, imiterere myiza yo gukora firime, hamwe nibisabwa muri farumasi nibikoresho byubwubatsi. Kurangiza, guhitamo bigomba gushingira kubitekerezo byuzuye kandi bigahuza nikoreshwa.
Igihe cyo kohereza: Gashyantare-21-2024