Hydroxypropylmethylcellulose (HPMC) ni inkomoko ya selile ikunze gukoreshwa mu nganda zitandukanye, harimo imiti, ubwubatsi n'ibiribwa. Ubukonje bwabwo burashobora gutandukana bitewe nuburemere bwa molekuline, urugero rwo gusimburwa, hamwe nibisubizo byibisubizo.
Intangiriro kuri Hydroxypropyl Methylcellulose (HPMC)
Hydroxypropyl methylcellulose ni polymer ya kimwe cya kabiri cyogukora hifashishijwe uburyo bwo guhindura imiti ya selile. Bitewe nimiterere yihariye, ikoreshwa cyane nkibyimbye, gelling agent, firime yahoze hamwe na stabilisateur mubikorwa bitandukanye.
Imiterere ya molekulari hamwe nibigize
HPMC igizwe numugongo wa selile hamwe na hydroxypropyl hamwe nimbaraga za metxy. Urwego rwo gusimbuza (DS) bivuga impuzandengo y'ibisimburwa kuri anhydroglucose murwego rwa selile. Agaciro DS yihariye igira ingaruka kumubiri na chimique ya HPMC.
HPMC
Viscosity ni ikintu cyingenzi kuri HPMC, cyane cyane muri porogaramu zikoresha umubyimba wacyo.
Ubukonje bwibisubizo bya HPMC bugira ingaruka kubintu byinshi:
1. Uburemere bwa molekile
Uburemere bwa molekuline ya HPMC bugira ingaruka kubwiza bwayo. Muri rusange, uburemere buke bwa HPMCs bukunda gutanga ibisubizo bihanitse. Hano hari amanota atandukanye ya HPMC kumasoko, buriwese ufite ibipimo byerekana uburemere bwa molekile.
2. Impamyabumenyi yo gusimbuza (DS)
Indangagaciro za DS za hydroxypropyl hamwe na mikorerexy matsinda bigira ingaruka kumyuka no kwiyegeranya kwa HPMC. Indangagaciro za DS murwego rwo hejuru zitera kwiyongera kwamazi hamwe nibisubizo binini.
3. Kwibanda
Kwishyira hamwe kwa HPMC mugisubizo nikintu cyingenzi kigira ingaruka kumaso. Mugihe kwibandaho kwiyongera, ubusanzwe ubwiyongere bwiyongera. Iyi sano ikunze gusobanurwa nuburinganire bwa Krieger-Dougherty.
4. Ubushyuhe
Ubushyuhe nabwo bugira ingaruka ku bwiza bwibisubizo bya HPMC. Muri rusange, ubukonje buragabanuka uko ubushyuhe bwiyongera.
Ahantu ho gusaba
Imiti ya farumasi: HPMC ikoreshwa muburyo bwa farumasi, harimo ibinini hamwe nibisubizo byamaso, aho bigenzurwa no kurekura bikabije.
Ubwubatsi: Mu nganda zubaka, HPMC ikoreshwa nkibyimbye mubicuruzwa bishingiye kuri sima kugirango bitezimbere imikorere no gufata neza amazi.
Inganda zikora ibiribwa: HPMC ikoreshwa nkibyimbye, stabilisateur na emulisiferi mugukoresha ibiryo.
Ubukonje bwa hydroxypropyl methylcellulose numutungo utoroshye wibasiwe nibintu byinshi nkuburemere bwa molekile, urugero rwo gusimburwa, kwibanda hamwe nubushyuhe. Ibyiciro bitandukanye bya HPMC birahari kugirango bikwiranye na porogaramu zihariye, kandi ababikora batanga impapuro za tekiniki zerekana urwego rwijimye rwa buri cyiciro mubihe bitandukanye. Abashakashatsi hamwe nabashinzwe gutegura bagomba gusuzuma ibi bintu kugirango bahuze imitungo ya HPMC kugirango bahuze ibyifuzo byabo.
Igihe cyo kohereza: Mutarama-20-2024