HPMC ni iki mu nganda zimiti?

Hydroxypropylmethylcellulose (HPMC) ni polymer ikora cyane ikoreshwa cyane mubikorwa bya farumasi. Ni mubyiciro bya selile ether kandi ikomoka kuri selile naturel. HPMC ikomatanyirizwa hamwe no kuvura selile hamwe na okiside ya propylene na methyl chloride, bikavamo ibivanze hamwe no gukemuka neza hamwe nibindi bintu byifuzwa. Iyi farumasi ikoreshwa cyane mugutezimbere no gukora imiti itandukanye, harimo ibinini, capsules, imyiteguro y'amaso hamwe na sisitemu yo gutanga imiti igenzurwa.

Intangiriro kuri hydroxypropyl methylcellulose:

Imiterere yimiti nimiterere:

Hydroxypropyl methylcellulose nigice cya sintetike, inert, polymer-soluble polymer. Imiterere yimiti irimo hydroxypropyl hamwe nitsinda ryimikorere ifatanye numugongo wa selile. Ingano yibi bisimbura irashobora gutandukana, bikavamo amanota atandukanye ya HPMC hamwe nibintu bitandukanye. Uburyo bwo gusimbuza bugira ingaruka nkibintu byijimye, gukomera, hamwe na gel.

Uburyo bwo gukora:

Umusaruro wa HPMC urimo etherifike ya selile hamwe na okiside ya propylene na methyl chloride. Urwego rwo gusimbuza (DS) rwamatsinda ya hydroxypropyl na mikorerexy irashobora kugenzurwa mugihe cya synthesis, bigatuma ubudozi bwimitungo ya HPMC busabwa muburyo bwo gufata imiti.

Ibisabwa mu nganda zimiti:

Guhambira muburyo bwa tablet:

HPMC ikoreshwa cyane nka binder muburyo bwa tablet. Ibikoresho byayo bifasha muguhuza ifu mubinini bikomeye. Kugenzura irekurwa ryibikoresho bya farumasi bikora (APIs) birashobora kugerwaho ukoresheje amanota yihariye ya HPMC hamwe nubwiza bukwiye hamwe ninzego zisimburwa.

Umukozi wa firime:

HPMC ikoreshwa nkibikoresho byo gutwika firime kubinini na granules. Itanga igifuniko kimwe cyo gukingira gitezimbere isura, uburyohe bwo guhisha no gutuza kumiterere ya dosiye. Byongeye kandi, imyenda ya HPMC irashobora guhindura imyirondoro yo gusohora ibiyobyabwenge.

Kurekurwa kuramba kandi kugenzurwa:

Imiterere ya hydrophilique yiyi polymer ituma ikwiriye gukoreshwa muburyo burambye kandi bugenzurwa-kurekura. Matrix ya HPMC yemerera kurekura ibiyobyabwenge mugihe kinini, kunoza kubahiriza abarwayi no kugabanya inshuro nyinshi.

Imyiteguro y'amaso:

Mu buryo bw'amaso, HPMC ikoreshwa mu kongera ububobere bw'amaso y'amaso, bityo igatanga igihe kirekire cyo gutura hejuru ya ocular. Ibi byongera ibiyobyabwenge bioavailability hamwe nubuvuzi bwiza.

Umuvuduko ukabije:

HPMC ikoreshwa nkibyimbye na stabilisateur mumazi na kimwe cya kabiri gikomeye nka geles, cream na suspensi. Itanga ubwiza kuriyi mikorere kandi ikanoza imiterere rusange ya rheologiya.

Ibintu by'ingenzi biranga HPMC:

Gukemura:

HPMC ibora mumazi kandi ikora igisubizo gisobanutse, kitagira ibara. Igipimo cyo guseswa kigira ingaruka ku rwego rwo gusimburwa no kurwego rwo hejuru.

Viscosity:

Ubwiza bwibisubizo bya HPMC nibyingenzi muguhitamo imikorere yabo mubikorwa bitandukanye. Impamyabumenyi zitandukanye ziraboneka hamwe nubwiza butandukanye, butanga kugenzura neza imiterere yimiterere yimiterere.

Ubushyuhe bwa Thermal:

Ibyiciro bimwe bya HPMC byerekana imiterere ya thermogelling, ikora geles mubushyuhe bwinshi. Uyu mutungo ukoreshwa mugutezimbere ubushyuhe.

guhuza:

HPMC irahujwe nubwoko butandukanye bwimiti yimiti na APIs, bigatuma ihitamo ryambere kubashinzwe gukora. Ntabwo ikora cyangwa ngo itesha agaciro ibintu byinshi bikora.

Inzitizi n'ibitekerezo:

Hygroscopicity:

HPMC ni hygroscopique, bivuze ko ikurura ubuhehere buturuka ku bidukikije. Ibi bigira ingaruka kumitekerereze no kugaragara, bityo rero kubika neza birakenewe.

Guhuza nibindi bicuruzwa:

Nubwo muri rusange bihuza, abategura bakeneye gutekereza ku guhuza HPMC n’ibindi bikoresho kugirango birinde imikoranire ishobora kugira ingaruka kumikorere.

Ingaruka kumurongo wo gusesa:

Guhitamo icyiciro cya HPMC birashobora kugira ingaruka zikomeye kumwirondoro wibiyobyabwenge. Uwashizeho agomba guhitamo neza icyiciro gikwiye kugirango agere kubyo yifuza kurekura.

Ibitekerezo bigenga:

HPMC yemerwa cyane nkibikoresho bya farumasi bifite umutekano kandi byiza. Yujuje ubuziranenge butandukanye kandi ishyirwa muri farumasi yisi yose. Ababikora bagomba gukurikiza uburyo bwiza bwo gukora (GMP) kugirango barebe ubuziranenge kandi buhoraho bwibicuruzwa bikoreshwa mu bya farumasi birimo HPMC.

mu gusoza:

Hydroxypropylmethylcellulose (HPMC), nkibintu byinshi kandi bikoreshwa cyane, bigira uruhare runini mubikorwa bya farumasi. Imiterere yihariye ituma ikoreshwa muburyo butandukanye bwa dosiye, harimo ibinini, capsules hamwe nubuvuzi bwamaso. Abashinzwe gukora inyungu bungukirwa no gushobora guhuza imitungo ya HPMC kugirango bujuje ibisabwa byihariye, nko kurekurwa kugenzurwa no gutezimbere. Nubwo hari ibibazo bimwe na bimwe, HPMC ikomeje kuba ingenzi mu iterambere ry’ibicuruzwa by’imiti byujuje ubuziranenge, bigira uruhare mu mutekano n’ingirakamaro by’imiti myinshi.