Ni ubuhe bwoko butandukanye bwa HPMC?

Hydroxypropyl Methylcellulose (HPMC) ni polymer itandukanye ikoreshwa mu nganda zitandukanye zirimo imiti, ubwubatsi, ibiryo, no kwisiga.Bikomoka kuri selile, polymer karemano iboneka mubihingwa.HPMC irashimwa cyane kubikorwa byayo byo gukora firime, kubyimba, gutuza, no kubika amazi.Mu nganda zimiti, ikoreshwa cyane nkibikoresho bya farumasi muburyo bwa dosiye yo mu kanwa, imyiteguro y’amaso, imiti yibanze, hamwe na sisitemu yo gutanga imiti igenzurwa.

HPMC irashobora gushyirwa mubikorwa hashingiwe ku bipimo byinshi birimo uburemere bwa molekile, urugero rwo gusimbuza, nubunini buke.Dore incamake yubwoko butandukanye bwa HPMC ukurikije ibi bipimo:

Ukurikije uburemere bwa Molecular:

Uburemere bukabije bwa molekuline HPMC: Ubu bwoko bwa HPMC bufite uburemere buke bwa molekile, biganisha ku kwiyongera kwijimye no gukora firime.Bikunze gukundwa mubisabwa aho bisabwa cyane cyane, nko kugenzura-kurekura.

Uburemere buke bwa molekuline HPMC: Ibinyuranye, uburemere buke bwa molekile HPMC ifite ubukonje buke kandi ikoreshwa mubisabwa aho ibyifuzo byo hasi no kwihuta vuba.

Ukurikije Impamyabumenyi yo Gusimbuza (DS):

Isimburwa ryinshi HPMC (HPMC-HS): HPMC ifite urwego rwo hejuru rwo gusimbuza ubusanzwe irerekana neza amazi meza kandi irashobora gukoreshwa muburyo busaba guseswa vuba.

Gusimbuza Hagati HPMC (HPMC-MS): Ubu bwoko bwa HPMC butanga uburinganire hagati yo kwikuramo no kwiyegeranya.Bikunze gukoreshwa muburyo butandukanye bwa farumasi.

Isimburwa Rito HPMC (HPMC-LS): HPMC ifite urwego rwo hasi rwo gusimbuza itanga umuvuduko wo gusesa buhoro hamwe nubwiza bwinshi.Bikunze gukoreshwa muburyo burambye-burekura dosiye.

Ukurikije Ingano ya Particle:

Ingano nziza ya HPMC: HPMC ifite ubunini buke butanga ibintu byiza kandi bigenda bikundwa muburyo bukomeye bwa dosiye nka tableti na capsules.

Ingano nini ya HPMC: Ibice bya Coarser birakwiriye kubisabwa aho bigenzurwa kurekurwa cyangwa kwagura-kurekura ibintu.Bikunze gukoreshwa mubitabo bya matrix na pellet.

Impamyabumenyi yihariye:

Enteric HPMC: Ubu bwoko bwa HPMC bwakozwe muburyo bwihariye bwo kurwanya amazi yo mu gifu, bigatuma ashobora kunyura mu gifu neza kandi akarekura imiti mu mara.Bikunze gukoreshwa kumiti yunvikana gastric pH cyangwa mugutanga intego.

Kurekura Kuramba HPMC: Izi formulaire zagenewe kurekura ibintu bikora buhoro buhoro mugihe kinini, biganisha kumiti igihe kirekire no kugabanya inshuro nyinshi.Bakunze gukoreshwa mubihe bidakira aho gukomeza ibiyobyabwenge bihoraho mumaraso.

Impamyabumenyi yo Guhuza:

HPMC-Acetate Succinate (HPMC-AS): Ubu bwoko bwa HPMC bukomatanya imiterere ya HPMC hamwe na acetyl, bigatuma bukwiranye na enteric na sisitemu yo gutanga imiti ya pH.

HPMC-Phthalate (HPMC-P): HPMC-P ni polymer ishingiye kuri pH ikunze gukoreshwa mu mwenda winjira mu rwego rwo kurinda ibiyobyabwenge indwara ya aside mu gifu.

Imvange yihariye:

Ababikora barashobora gukora imvange ya HPMC hamwe nizindi polymers cyangwa ibicuruzwa kugirango bagere kubisabwa byihariye nko kunoza imyirondoro yo gusohora ibiyobyabwenge, kongera umutekano, cyangwa uburyohe bwo guhisha uburyohe.

imitungo itandukanye ya HPMC yemerera kuyikoresha muburyo butandukanye bwimiti ya farumasi, buri kimwe cyujuje ibisabwa byihariye nko kwikemurira ibibazo, kwiyegeranya, kurekura kinetika, no gutuza.Gusobanukirwa ubwoko butandukanye bwa HPMC nibiranga nibyingenzi kubashinzwe gutegura uburyo bwiza bwo gutanga ibiyobyabwenge.