Hypromellose, izwi kandi nka hydroxypropyl methylcellulose (HPMC), ni polimeri itandukanye igizwe na polimeri ikomoka kuri selile. Bitewe n'imiterere yihariye ya chimique na physique, HPMC isanzwe ikoreshwa nkibyimbye, stabilisateur hamwe na afashe mubikorwa bya farumasi, ibiryo ndetse no kwita kubantu. Muri iki kiganiro, turaganira kuri chimie ya HPMCs nibisabwa byingenzi.
1. Gukemura
Imwe mu miterere yingenzi yimiti ya HPMC nubushobozi bwayo. HPMC irashobora gushonga mumazi hamwe nudukoko twinshi twinshi, bigatuma iba ikintu cyiza muburyo bwo gutanga ibiyobyabwenge nibindi bikorwa bisaba guseswa. Nyamara, gukomera kwa HPMC kugenwa ahanini nurwego rwasimbuwe (DS), rugena umubare wamatsinda ya hydroxypropyl na methyl biboneka mumurongo wa polymer. HPMCs hamwe na DS yo hejuru ifite ubushobozi buke bwo gukemura bitewe no kwiyongera kwimikoranire.
2. Rheologiya
Undi mutungo wingenzi wa HPMC ni imyitwarire ya rheologiya. Ubushobozi bwa HPMC bwo gukora umuyoboro umeze nka gel kuri hydration irashobora gukoreshwa mugucunga ibishishwa nibiranga imiterere. HPMC irerekana kandi imyitwarire itari iya Newtonian, bivuze ko ububobere bwayo buhinduka ukurikije igipimo cyogosha. Uyu mutungo urashobora kugenzurwa muguhindura ubunini bwa HPMC na DS muburyo bwo gukora.
3. Gushiraho firime
HPMC nayo ikoreshwa cyane nka firime yahoze kubera ubushobozi bwayo bwo gukora firime imwe iyo ikoreshejwe kuri substrate. Imiterere ya firime ya HPMC iterwa na DS yayo, ubukonje ndetse no kuba hari plasitike, bishobora kunoza imiterere nubworoherane bwa firime. Filime zakozwe muri HPMC zikoreshwa cyane mugutanga ibiyobyabwenge kuko zemerera kurekurwa kugenzura ibintu bikora.
4. Guhuza
HPMC ni ibintu bihuza cyane kandi birashobora gukoreshwa muburyo butandukanye. Ihuza nibikoresho byinshi bya farumasi, harimo ibikoresho bya farumasi bikora (APIs) nibindi bikoresho bisanzwe bikoreshwa mumiti. HPMC nayo ihujwe nibintu byinshi byokurya, bigatuma ihitamo gukundwa no gukoresha ibiryo.
5. Gutunganya imiti
HPMC ni polymer ihamye irwanya hydrolysis nibindi bintu bivura imiti. Uku gushikama gutuma kuba ikintu cyiza muri sisitemu yo gutanga ibiyobyabwenge kuko irinda ibintu bikora kwangirika kandi byongera bioavailability. Nyamara, imiti ihamye ya HPMC irashobora guterwa nubushyuhe bwo hejuru, ubuhehere bwinshi, hamwe nudukoko tumwe na tumwe, ibyo bikaba bishobora gutuma polymer yangirika kandi bikagabanya imikorere yabyo.
6. Biocompatibilité
Hanyuma, HPMC ni polymer biocompatable cyane ifite umutekano mukoresha mumiti yimiti nibicuruzwa byumuntu. Ntabwo ari uburozi, butari ubudahangarwa na biodegradable, bigatuma biba byiza kubisobanuro bisaba uburozi buke n'umutekano ntarengwa.
Muri make, HPMC hypromellose ni polymer ikora cyane hamwe nibintu bitandukanye byingenzi bya shimi, harimo gukemura, rheologiya, imiterere ya firime, guhuza, gutuza imiti, hamwe na biocompatibilité. Iyi mitungo ituma iba nziza cyane muri sisitemu yo gutanga ibiyobyabwenge nibindi bikorwa mubiribwa ninganda zita kubantu. Mugihe ubushakashatsi bukomeje kwagura imyumvire yacu kuri HPMCs, imitungo yabo idasanzwe irashobora kubona porogaramu yagutse mugihe kizaza.
Igihe cyo kohereza: Nyakanga-28-2023