Viscosity Ibintu bya Hydroxypropyl Methylcellulose (HPMC)

Hydroxypropyl Methylcellulose (HPMC) ningirakamaro ya selulose ether ikomoka cyane mubikorwa byinshi byinganda kubera imiterere yihariye yumubiri na chimique. Imiterere yacyo ya viscosity nimwe mubintu byingenzi bya HPMC, bigira ingaruka kumikorere yayo mubikorwa bitandukanye.

1. Ibintu shingiro bya HPMC
HPMC ni ether ya selulose ether yabonetse mugusimbuza igice cyamatsinda ya hydroxyl (–OH) muri molekile ya selile hamwe nitsinda ryimikorere (–OCH3) hamwe nitsinda rya hydroxypropyl (–OCH2CH (OH) CH3). Ifite imbaraga zo gukama neza mumazi hamwe na solge zimwe na zimwe, bikora ibisubizo bya mucyo. Ubukonje bwa HPMC bugenwa ahanini nuburemere bwa molekile, urugero rwo gusimburwa (DS, Impamyabumenyi yo gusimbuza) no gukwirakwiza insimburangingo.

2. Kumenya ubwiza bwa HPMC
Ubukonje bwibisubizo bya HPMC mubusanzwe bipimwa hifashishijwe viscometer izunguruka cyangwa capillary viscometer. Iyo upimye, hagomba kwitabwaho kwibanda ku bushyuhe, ubushyuhe n’igipimo cy’igisubizo cy’ibisubizo, kuko ibyo bintu bishobora kugira ingaruka zikomeye ku gaciro keza.

Kwibanda kumuti: Ubukonje bwa HPMC bwiyongera hamwe no kwiyongera kwibisubizo. Iyo kwibumbira hamwe kwa HPMC ari bike, imikoranire hagati ya molekile iba idakomeye kandi ubwiza buri hasi. Mugihe kwibanda kwiyongera, guhuzagurika no gukorana hagati ya molekile biriyongera, bigatuma ubwiyongere bugaragara cyane.

Ubushyuhe: Ubukonje bwibisubizo bya HPMC bwumva cyane ubushyuhe. Mubisanzwe, uko ubushyuhe bwiyongera, ubwiza bwumuti wa HPMC buzagabanuka. Ibi biterwa nubushyuhe bwiyongera buganisha kuri molekile igenda yiyongera no guhuza imikoranire ya intermolecular. Twabibutsa ko HPMC ifite impamyabumenyi zitandukanye zo gusimbuza hamwe nuburemere bwa molekile bifite sensibilité zitandukanye kubushyuhe.

Igipimo cyogosha: HPMC ibisubizo byerekana imyitwarire ya pseudoplastique (shear thinning), ni ukuvuga ko ubukonje buri hejuru kurwego rwo hasi kandi bikagabanuka kurwego rwo hejuru. Iyi myitwarire iterwa nimbaraga zo gukata zihuza iminyururu ya molekulari yerekeza ku cyerekezo cyogosha, bityo bikagabanya imikoranire n'imikoranire hagati ya molekile.

3. Ibintu bigira ingaruka kuri HPMC
Uburemere bwa molekuline: Uburemere bwa molekuline ya HPMC nimwe mubintu byingenzi bigena ubwiza bwayo. Muri rusange, uko uburemere bwa molekile nini, niko ubwiza bwibisubizo. Ni ukubera ko molekile ya HPMC ifite uburemere buke bwa molekile birashoboka cyane gukora imiyoboro ifatanye, bityo bikongerera ubushyamirane bwimbere bwigisubizo.

Impamyabumenyi yo gusimbuza no gukwirakwiza insimburangingo: Umubare nogukwirakwiza metxyxy na hydroxypropyl insimburangingo muri HPMC nabyo bigira ingaruka kumyuka yacyo. Mubisanzwe, urwego rwo hejuru rwo gusimbuza imikorere (DS), niko igabanuka ryubwiza bwa HPMC, kuko kwinjiza insimburangingo ya mikorobe bizagabanya imbaraga za hydrogène ihuza molekile. Kwinjiza insimburangingo ya hydroxypropyl bizongera imikoranire hagati yimitsi, bityo byongere ubwiza. Byongeye kandi, gukwirakwiza kimwe kubisimbuza bifasha gukora sisitemu ihamye yo gukemura no kongera ubwiza bwigisubizo.

pH agaciro k'igisubizo: Nubwo HPMC ari polymer itari ionic kandi viscosity yayo ntabwo yunvikana nimpinduka mugiciro cya pH cyigisubizo, indangagaciro za pH zikabije (acide cyane cyangwa alkaline cyane) zishobora gutera kwangirika kwimiterere ya molekile ya HPMC, bityo bigira ingaruka ku bwiza.

4. Imirima ikoreshwa ya HPMC
Bitewe nubwiza buhebuje, HPMC ikoreshwa cyane mubice byinshi:

Ibikoresho byubwubatsi: Mubikoresho byubwubatsi, HPMC ikoreshwa nkibikoresho binini kandi bigumana amazi kugirango tunoze imikorere yubwubatsi kandi byongere imbaraga zo guhangana.

Uruganda rwa farumasi: Mu nganda zimiti, HPMC ikoreshwa nkumuhuza wibinini, umukozi ukora firime ya capsules hamwe nogutwara imiti irekura.

Inganda zibiribwa: HPMC ikoreshwa nkibyimbye kandi bigahindura inganda zikora ibiryo kugirango habeho ice cream, jelly n’ibikomoka ku mata.

Ibicuruzwa bya chimique bya buri munsi: Mubicuruzwa bya chimique bya buri munsi, HPMC ikoreshwa nkibyimbye na stabilisateur kugirango ikore shampoo, gel yogesha, amenyo yinyo, nibindi.

Ibiranga ubwiza bwa HPMC nibyo shingiro ryimikorere myiza mubikorwa bitandukanye. Mugucunga uburemere bwa molekuline, urwego rwo gusimburwa, hamwe nuburyo bwo gukemura ibibazo bya HPMC, ububobere bwayo burashobora guhinduka kugirango bikemure ibyifuzo bitandukanye. Mu bihe biri imbere, ubushakashatsi bwimbitse ku isano iri hagati yimiterere ya molekile ya HPMC nubukonje bizafasha guteza imbere ibicuruzwa bya HPMC nibikorwa byiza no kurushaho kwagura ibikorwa byayo.