HydroxyPropyl MethylCellulose (HPMC)

Hydroxypropyl Methylcellulose (HPMC), izwi kandi nka hypromellose, ni polymer itandukanye ikomoka kuri selile. Ikoreshwa cyane mu nganda zinyuranye kumiterere yihariye, harimo imiti, ubwubatsi, ibiryo, kwisiga, no kwita kubantu. Muri iki gitabo cyuzuye, tuzasesengura imiterere yimiti, imitungo, uburyo bwo gukora, porogaramu, ninyungu za HPMC muburyo burambuye.

1. Intangiriro kuri HPMC:

Hydroxypropyl Methylcellulose (HPMC) ni ether selile ionic selulose ether ikomoka kuri selile naturel binyuze muburyo bwo guhindura imiti. Ihindurwamo no kuvura selile hamwe na oxyde ya propylene na methyl chloride kugirango itangize hydroxypropyl na methyl mumatsinda ya selile. Polimeri yavuyemo yerekana ibintu bitandukanye bituma igira agaciro gakomeye mubikorwa bitandukanye byinganda.

2. Imiterere yimiti nibyiza:

HPMC irangwa nimiterere yimiti, igizwe numugongo wa selile hamwe na hydroxypropyl hamwe na methyl insimburangingo ifatanye nitsinda rya hydroxyl. Urwego rwo gusimbuza (DS) rwamatsinda ya hydroxypropyl na methyl rushobora gutandukana, bikavamo amanota atandukanye ya HPMC hamwe nibintu bitandukanye nka viscosity, solubilité, hamwe nimyitwarire ya gelation.

Imiterere ya HPMC iterwa nibintu nkuburemere bwa molekile, urugero rwo gusimburwa, hamwe na hydroxypropyl / methyl. Muri rusange, HPMC yerekana ibintu by'ingenzi bikurikira:

• Amazi meza
• Ubushobozi bwo gukora firime
• Umubyimba no gusya
• Igikorwa cyo hejuru
• Guhagarara hejuru ya pH yagutse
• Guhuza nibindi bikoresho

3. Uburyo bwo gukora:

Umusaruro wa HPMC urimo intambwe nyinshi, harimo:

1. Gutegura Cellulose: Cellulose isanzwe, ikomoka mubiti cyangwa ipamba, isukurwa kandi inonosorwa kugirango ikureho umwanda na lignine.
2. Imyitwarire ya Etherification: Cellulose ivurwa na oxyde ya propylene na methyl chloride imbere ya catalizike ya alkali kugirango itangize hydroxypropyl na methyl mumatsinda ya selile.
3. Kutabogama no Gukaraba: Ibicuruzwa bivamo bidafite aho bibogamiye kugirango bikureho alkali irenze hanyuma ikarabe kugirango ikureho ibicuruzwa n’umwanda.
4. Kuma no gusya: HPMC isukuye yumishijwe hanyuma igahinduka ifu nziza ikwiranye nuburyo butandukanye.

4. Impamyabumenyi n'ibisobanuro:

HPMC iraboneka murwego rwamanota hamwe nibisobanuro byujuje ibisabwa byinganda zitandukanye nibisabwa. Ibi birimo gutandukana mubwiza, ingano yingingo, urwego rwo gusimburwa, nubushyuhe bwa gelation. Ibyiciro rusange bya HPMC birimo:

• Ibyiciro bya viscosity bisanzwe (urugero, 4000 cps, 6000 cps)
• Impamyabumenyi yo hejuru cyane (urugero, 15000 cps, 20000 cps)
• Impamyabumenyi yo hasi (urugero, 1000 cps, 2000 cps)
• Amanota yihariye kubisabwa byihariye (urugero, kurekura kuramba, kurekurwa kugenzurwa)

5. Porogaramu ya HPMC:

HPMC isanga ikoreshwa cyane mu nganda zinyuranye bitewe nuburyo butandukanye kandi ihuza nibikoresho bitandukanye. Bimwe mubikorwa byingenzi bya HPMC birimo:

a. Inganda zimiti:

• Ibinini bya tableti na capsule
• Kugenzura ibyasohotse
• Guhambira hamwe no gutandukanya ibice
• Amaso yubuvuzi nibihagarikwa
• Ibyingenzi byingenzi nka cream n'amavuta

b. Inganda zubaka:

• Ibicuruzwa bishingiye kuri sima na gypsumu (urugero, minisiteri, plaster)
• Amashanyarazi hamwe na grout
• Sisitemu yo hanze no kurangiza (EIFS)
• Kwishyira hamwe
• Amabara ashingiye kumazi

c. Inganda zikora ibiribwa:

• Umubyimba no gutuza mubicuruzwa byibiribwa
• Emulsifier no guhagarika agent muri sosi no kwambara
• Ibiryo byongera ibiryo
• Gluten idafite guteka no guteka

d. Kwitaho no kwisiga:

• Thickener no guhagarika agent mumavuta yo kwisiga hamwe na cream
• Binder na firime-yambere mubicuruzwa byita kumisatsi
• Kugenzurwa kurekurwa muburyo bwo kuvura uruhu
• Amaso atonyanga hamwe na lens ibisubizo

6. Inyungu zo gukoresha HPMC:

Gukoresha HPMC bitanga inyungu nyinshi mubikorwa bitandukanye:

• Kunoza imikorere yibicuruzwa nubuziranenge
• Kuzamura imiterere ihindagurika kandi ihamye
• Kongera igihe cyo kuramba no kugabanya kwangirika
• Kunoza imikorere neza no gukoresha neza
• Kubahiriza ibisabwa n'amategeko agenga umutekano
• Ibidukikije byangiza ibidukikije na biocompatible

7. Ibizaza hamwe n'ibitekerezo:

Biteganijwe ko icyifuzo cya HPMC kizakomeza kwiyongera, bitewe n’impamvu nko kongera imijyi, iterambere ry’ibikorwa remezo, hamwe n’ibicuruzwa bikomoka ku miti no kwita ku muntu ku giti cye. Imbaraga zikomeje gukorwa mubikorwa byiterambere byibanze mugutezimbere imikorere ya HPMC, kwagura imikoreshereze yayo, no kunoza imikorere yinganda kugirango isoko ryiyongere.

8. Umwanzuro:

Hydroxypropyl Methylcellulose (HPMC) ni polymer itandukanye kandi ikoreshwa muburyo butandukanye mu nganda nyinshi. Imiterere yihariye, nko gukemura amazi, ubushobozi bwo gukora firime, hamwe nubunini bwimbitse, bituma igira agaciro gakomeye mumiti yimiti, ubwubatsi, ibiryo, kwita kumuntu, no kwisiga. Mugihe ikoranabuhanga ritera imbere nibisabwa ku isoko bigenda byiyongera, HPMC biteganijwe ko izagira uruhare runini mugushiraho ejo hazaza h’inganda zitandukanye.