Kurenza ubwiza bwaHPMChydroxypropyl methyl selulose, nibikorwa byiza byo gufata amazi. Viscosity nikintu cyingenzi cyimikorere ya HPMC. Kugeza ubu, abakora HPMC batandukanye bakoresha uburyo nibikoresho bitandukanye kugirango bamenye ubwiza bwa HPMC. Uburyo nyamukuru ni Haake Rotovisko, Hoppler, Ubbelohde na Brookfield, nibindi
Kubicuruzwa bimwe, ibisubizo bya viscosity byapimwe nuburyo butandukanye biratandukanye cyane, bimwe nibitandukaniro byinshi. Kubwibyo, mugihe ugereranije viscosity, bigomba gukorwa hagati yuburyo bumwe bwikizamini, harimo ubushyuhe, rotor, nibindi.
Kubunini buke, nibyiza cyane, niko gufata amazi neza. Ibice binini bya selulose ether ihura namazi, hejuru ihita ishonga hanyuma igakora gel kugirango ipfundike ibikoresho kugirango irinde molekile zamazi gukomeza kwinjira, rimwe na rimwe umwanya muremure ntushobora gukwirakwira neza gushonga, gushiraho igisubizo cyibyondo cyangwa ibyondo cyangwa aglomerate. Ubushobozi bwa selile ether ni kimwe mubintu byo guhitamo selile. Ubwiza nabwo ni indangagaciro yingenzi ya methyl selulose ether. MC kuri minisiteri yumye isaba ifu, amazi make, hamwe nubunini bwa 20% ~ 60% ingano ya 63um. Ubwiza bugira ingaruka kubishoboraHPMChydroxypropyl methyl selulose ether. Ubusanzwe MC isanzwe ni granulaire kandi irashobora gushonga byoroshye mumazi idateranije, ariko umuvuduko wo gushonga uratinda cyane, kubwibyo ntibikwiriye gukoreshwa mumashanyarazi yumye. Muri minisiteri yumye, MC ikwirakwizwa hagati yuzuye, yuzuza neza nibikoresho bya sima nka sima, kandi ifu yonyine ihagije irashobora kwirinda gufatira methyl selulose ether mugihe ivanze namazi. Iyo MC yongeyeho amazi yo gushonga agglomerate, biragoye cyane kuyitatanya no kuyashonga. MC ifite ubwiza buke ntabwo ari imyanda gusa, ahubwo inagabanya imbaraga zaho za minisiteri. Iyo minisiteri yumye yubatswe ahantu hanini, umuvuduko wo gukiza wa minisiteri yumye iragabanuka cyane, bikavamo gucika biterwa nigihe cyo gukira. Kubikoresho byo gutera imashini, kubera igihe gito cyo kuvanga, ubwiza buri hejuru.
Muri rusange, uko ubukonje buri hejuru, ningaruka nziza yo gufata amazi. Nyamara, uko ubukonje buri hejuru, niko uburemere bwa molekile ya MC buri hejuru, kandi imikorere yo gusesa izagabanuka uko bikwiye, bigira ingaruka mbi kumbaraga no mubikorwa bya minisiteri. Iyo hejuru yubukonje, niko bigaragara cyane kubyimbye bya minisiteri, ariko ntabwo bihuye nubusabane. Iyo hejuru yubukonje, minisiteri itose izarushaho gukomera, haba mubwubatsi, imikorere ya scraper yometse hamwe no gufatira hejuru kubintu fatizo. Ariko ntabwo ari byiza kongera imbaraga zimiterere ya minisiteri itose. Mugihe cyo kubaka, imikorere irwanya sag ntabwo igaragara. Ibinyuranye na byo, methyl selulose ethers yahinduwe neza ifite imikorere myiza mugutezimbere imbaraga zububiko bwa minisiteri.
Kurenza selile ya selile yongewe kuri minisiteri, imikorere myiza yo gufata amazi, niko hejuru yubukonje, nuburyo bwiza bwo gufata amazi.
Ubwiza bwa HPMC nabwo bugira ingaruka runaka kubigumana byamazi, muri rusange, kubwubukonje bumwe nubwiza butandukanye bwa methyl selulose ether, mugihe hiyongereyeho ubwinshi, ibyiza byo gufata amazi nibyiza.
Kugumana amazi ya HPMC nabyo bifitanye isano n'ubushyuhe bwo gukoresha, kandi kubika amazi ya methyl selulose ether bigabanuka hamwe n'izamuka ry'ubushyuhe. Ariko mubikorwa bifatika bifatika, ibidukikije byinshi bya minisiteri yumye akenshi bizaba biri mubushyuhe bwo hejuru (hejuru ya dogere 40) mugihe cyo kubaka muri substrate ishyushye, nko kwizuba ryizuba ryurukuta rwinyuma rushyizwemo plaque, akenshi byihutisha gukomera kwa sima na minisiteri yumye gukomera. Kugabanuka kw'igipimo cyo gufata amazi biganisha ku kumva ko imyubakire ndetse no kurwanya ibice bigira ingaruka. Muri ubu buryo, kugabanya ingaruka ziterwa nubushyuhe biba ingenzi cyane. Nubwo inyongeramusaruro ya methyl hydroxyethyl selulose ether ifatwa nkaho iri ku isonga mu iterambere ry’ikoranabuhanga, kuba biterwa n'ubushyuhe bizakomeza gutuma intege nke za minisiteri yumye. Ndetse hamwe no kwiyongera kwa methyl hydroxyethyl selulose ya dosiye (formula yo mu cyi), kurwanya no gucika intege ntibishobora guhaza ibikenewe gukoreshwa. Binyuze mu buryo bwihariye bwo kuvura MC, nko kongera urugero rwa etherification, ingaruka yo gufata amazi ya MC irashobora gukomeza ingaruka nziza munsi yubushyuhe bwinshi, kuburyo ishobora gutanga imikorere myiza mubihe bibi.
Igihe cyo kohereza: Gicurasi-18-2022