Imiterere ya HPMC

HPMC yitwa hydroxypropyl methylcellulose.

Ibicuruzwa bya HPMC bitoranya ipamba ya selile nziza cyane nkibikoresho fatizo kandi bikozwe na etherification idasanzwe mubihe bya alkaline. Inzira yose yarangiye mubihe bya GMP no kugenzura byikora, nta bikoresho bifatika nkibice byinyamanswa hamwe namavuta.

Umutungo wa HPMC:

Ibicuruzwa bya HPMC ntabwo ari ionic selulose ether, isura ni ifu yera, idafite uburyohe butagira impumuro nziza, gushonga mumazi hamwe nudukoko twinshi twa polarike (nka dichloroethane) hamwe nigipimo gikwiye cya Ethanol / amazi, inzoga ya propyl / amazi, nibindi. Igisubizo cyamazi gifite ubuso ibikorwa, gukorera mu mucyo no gukora neza. HPMC ifite imiterere ya gel yumuriro, igisubizo cyamazi yubushyuhe arashyuha kugirango habeho imvura igwa, hanyuma igashonga nyuma yo gukonja, ibintu bitandukanye byubushyuhe bwa geli buratandukanye. Ubushobozi bwo guhinduka hamwe nubwiza, hasi yubukonje, niko bigenda byiyongera, ibisobanuro bitandukanye bya HPMC bifite itandukaniro runaka mumiterere yabyo, HPMC mumazi ntabwo ihindurwa nagaciro ka PH. Ingano ya Particle: igipimo cya mesh 100 irenga 100%. Ubucucike bwinshi: 0.25-0.70g / (mubisanzwe hafi 0.5g /), uburemere bwihariye 1.26-1.31. Ubushyuhe bwo guhindura ibara: 190-200 ℃, ubushyuhe bwa karubone: 280-300 ℃. Ubushyuhe bwo hejuru: 42-56dyn / cm muri 2% yumuti wamazi. Hamwe no kwiyongera kwibintu bya mikorerexyl, ingingo ya gel yagabanutse, gukomera kwamazi byariyongereye, kandi ibikorwa byo hejuru nabyo byariyongereye. HPMC ifite ibiranga kubyimbye, umunyu, ibirimo ivu rike, PH ihagaze neza, kubika amazi, guhagarara neza, gukora firime nziza no kurwanya cyane enzyme, gutandukana no gufatanya.

Porogaramu ya HPMC:

1. Ipitingi ya tablet: HPMC ikoreshwa nkibikoresho byo gutwika firime mugutegura gukomeye, irashobora gukora firime ikomeye, yoroshye kandi nziza, ikoreshwa rya 2% -8%. Nyuma yo gutwikira, ituze ryumukozi kumucyo, ubushyuhe nubushuhe byiyongera; Uburyohe kandi butagira impumuro nziza, byoroshye gufata, hamwe na HPMC pigment, izuba ryizuba, amavuta nibindi byiza bihuza ibikoresho. Igifuniko gisanzwe: amazi cyangwa 30-80% Ethanol yo gushonga HPMC, hamwe nigisubizo cya 3-6%, wongeyeho ibikoresho bifasha (nka: ubushyuhe bwubutaka -80, amavuta ya castor, PEG400, talc, nibindi).

2. Enteric-soluble coating layer layer: hejuru ya tableti na granules, HPMC yabanje gukoreshwa nkigice cyo hasi cyo kwigunga, hanyuma igashyirwa hamwe na HPMCP enteric-soluble material. Filime ya HPMC irashobora kunoza ituze rya enteric-soluble coating agent mububiko.

3. Gutegura kuramba-kurekura: gukoresha HPMC nkibikoresho bitera pore no kwishingikiriza kuri Ethyl selulose nkibikoresho bya skeleton, kurekura-kurekura ibinini bikora igihe kirekire birashobora gukorwa.

4. Umuti wibyimbye hamwe na colloid ikingira hamwe nigitonyanga cyamaso: HPMC kumubyimba ukunze gukoreshwa kuri 0.45-1%.

5. Ibifatika: HPMC nkumuhuza rusange wa 2% -5%, ikoreshwa mugutezimbere ituze rya hydrophobique, ikoreshwa cyane kuri 0.5-1.5%.

6. Gutinda umukozi, kugenzura kurekura no kugenzura. Umukozi uhagarikwa: dosiye isanzwe yumukozi uhagarika ni 0.5-1.5%.

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8. Ikoreshwa mu kwisiga nkibikoresho, emulisiferi, ibikoresho byo gukora firime, nibindi.