Hydroxypropyl methylcellulose (HPMC) ni polymer ikora cyane hamwe nibikorwa byinshi mubikorwa bitandukanye nka farumasi, ubwubatsi, ibiryo, kwisiga, nibindi. Dore ubushakashatsi bwimbitse kuri HPMC:
1. Ibiranga HPMC:
Imiterere yimiti: HPMC ikomoka kuri selile, polymer karemano iboneka mubihingwa. Ihinduranya muguhindura selile hamwe na selile ya propylene na methyl chloride. Urwego rwo gusimbuza hydroxypropyl hamwe na mikorerexy matsinda igena imiterere yabyo.
Gukemura: HPMC irashonga mumazi hejuru yubushyuhe bugari. Gukemura biterwa nurwego rwo gusimbuza nuburemere bwa molekuline ya polymer. Urwego rwo hejuru rwo gusimbuza rutera kwiyongera kwamazi.
Viscosity: HPMC yerekana imyitwarire ya pseudoplastique cyangwa yogosha, bivuze ko ububobere bwayo bugabanuka mugihe cyo guhangayika. Ubwiza bwibisubizo bya HPMC burashobora guhindurwa muguhindura ibipimo nkuburemere bwa molekile, urwego rwo gusimburwa, hamwe nibitekerezo.
Imiterere ya firime: HPMC ikora firime zisobanutse kandi zoroshye mugihe zashizwe mubisubizo. Imiterere ya firime irashobora guhindurwa muguhindura polymer yibanze hamwe na plasitike.
Ubushyuhe bwumuriro: HPMC ifite ubushyuhe bwiza bwumuriro, hamwe nubushyuhe bwangirika mubisanzwe hejuru ya 200 ° C. Ibi bituma bikwiranye nuburyo butandukanye bwo gutunganya, harimo gushonga gushushe no gushiramo inshinge.
Hydrophilicity: Kubera imiterere ya hydrophilique, HPMC irashobora gukuramo no kugumana amazi menshi. Uyu mutungo ufite akamaro mubisabwa nko kugenzura-kurekura ibiyobyabwenge no gutanga umubyimba muri sisitemu y'amazi.
Guhuza: HPMC irahujwe nibindi bikoresho bitandukanye, harimo izindi polymers, plasitike, nibikoresho bya farumasi bikora (APIs). Uku guhuza kwemerera sisitemu igoye gutegurwa hamwe nibintu byihariye.
Ibintu bitari ionic: HPMC ni polymer itari ionic, bivuze ko idatwara umuriro w'amashanyarazi. Uyu mutungo ugabanya imikoranire nubwoko bwishyuzwa muburyo bwo gukora kandi byongera ituze mubisubizo.
Imikorere ya HPMC:
Binders: Mubisobanuro bya tableti, HPMC ikora nkumuhuza, iteza imbere guhuza ibice no kongera imbaraga za tekinike ya tablet. Ifasha kandi ibinini gusenyuka nyuma yo kurya.
Ipitingi ya firime: HPMC ikoreshwa cyane nkibikoresho byo gutwika firime kubinini na capsules. Ikora igifuniko kimwe, kirinda guhisha uburyohe numunuko wibiyobyabwenge, byongera umutekano, kandi byoroha kumira.
Irekurwa rirambye: HPMC irashobora gukoreshwa mugucunga igipimo cyo kurekura imiti kuva kumiti ya farumasi. Mugihe cyo gukora geli, HPMC irashobora gutinza ibiyobyabwenge kandi igatanga ingaruka zihoraho zo kuvura.
Guhindura Viscosity: Muri sisitemu y'amazi, HPMC ikora nka modifier ya viscosity cyangwa ikabyimbye. Itanga imyitwarire ya pseudoplastique, itezimbere ituze hamwe nogukoresha imikorere yimikorere nka cream, amavuta yo kwisiga hamwe na geles.
Guhagarika ibikorwa: HPMC ikoreshwa muguhagarika ihagarikwa ryibice bitangirika mumashanyarazi. Irinda gutuza yongera ubwiza bwicyiciro gikomeza no kongera ibice bitatanye.
Emulsifier: Mubisobanuro bya emulsiyo, HPMC ihindura intera hagati yicyiciro cyamavuta namazi, ikumira gutandukanya ibyiciro na emulisation. Itezimbere ituze hamwe nubuzima bwamavuta yo kwisiga mubicuruzwa nka cream, amavuta n'amavuta yo kwisiga.
Imiterere ya Hydrogel: HPMC irashobora gukora hydrogène iyo ihinduwe neza, ikagira akamaro mukwambara ibikomere, lens ya contact, hamwe na sisitemu yo gutanga ibiyobyabwenge. Izi hydrogels zitanga ibidukikije bitose kugirango bikire ibikomere kandi birashobora gupakira imiti yo kubyara.
Umukozi wo kubyimba: HPMC isanzwe ikoreshwa nkibintu byiyongera mubicuruzwa byibiribwa nka sosi, imyambarire hamwe nubutayu. Itanga uburyo bwiza kandi ikongerera uburyohe idahinduye uburyohe cyangwa intungamubiri.
Inyongera zubwubatsi: Mu nganda zubaka, HPMC ikoreshwa nkibikoresho bigumana amazi muri minisiteri ishingiye kuri sima na plasta. Itezimbere gukora, gufatira hamwe, no kugabanya gucikamo umuvuduko mwamazi.
Guhindura Ubuso: HPMC irashobora guhindura imiterere yimiterere yubutaka bukomeye nkimpapuro, imyenda nubutaka. Itezimbere gucapura, gufatira hamwe nimbogamizi yimyenda ya firime.
Hydroxypropylmethylcellulose (HPMC) ni polymer itandukanye hamwe nibintu bitandukanye nibikorwa. Gukemura kwayo, kwiyegeranya, ubushobozi bwo gukora firime no guhuza bituma iba ikintu cyingirakamaro mubikorwa byinshi mubikorwa byinganda. Kuva muri farumasi kugeza mubwubatsi, ibiryo kugeza kwisiga, HPMC ikomeje kugira uruhare runini mukuzamura imikorere nubuziranenge. Mugihe ubushakashatsi nikoranabuhanga bigenda bitera imbere, ibintu byinshi nibikorwa bya HPMC birashobora kurushaho kwaguka, bigatera udushya mugushushanya no guteza imbere ibicuruzwa.
Igihe cyo kohereza: Gashyantare-23-2024