Hydroxypropyl methylcellulose (HPMC), nkibikomoka kuri selile isanzwe, ikoreshwa cyane mubwubatsi, imiti, ibiryo, imiti ya buri munsi nizindi nganda. Ubwiza bwa HPMC bugenzurwa cyane cyane mubice byimiterere yumubiri na chimique, imikorere ikora ningaruka zo gukoresha.
1. Kugaragara n'ibara
Ubusanzwe HPMC yera cyangwa ifu yera cyangwa granules. Niba hari ibara ryingenzi rihinduka, nkumuhondo, imvi, nibindi, birashobora gusobanura ko ubuziranenge bwabwo butari hejuru cyangwa bwanduye. Mubyongeyeho, uburinganire bwubunini bugaragaza kandi urwego rwo kugenzura ibikorwa. Ibice byiza bya HPMC bigomba kugabanwa neza nta agglomeration igaragara cyangwa umwanda.
2. Ikizamini cyo gukemura
HPMC ifite amazi meza, nicyo kimenyetso cyingenzi cyo gusuzuma ubuziranenge bwacyo. Binyuze mu kizamini cyoroshye cyo gusesa, igisubizo cyacyo hamwe nubwiza bwacyo birashobora gusuzumwa. Intambwe nizi zikurikira:
Fata ifu ya HPMC nkeya, uyongereho buhoro buhoro mumazi akonje cyangwa amazi yubushyuhe bwicyumba, hanyuma urebe uburyo bwo kuyasesa. HPMC yo mu rwego rwohejuru igomba gukwirakwizwa mu gihe gito nta mvura igaragara igaragara, hanyuma igashiraho igisubizo kiboneye cyangwa gike cyane.
Igipimo cyo gusesa HPMC gifitanye isano nimiterere ya molekile, urugero rwo gusimburwa, hamwe nuburyo bwera. HPMC idafite ubuziranenge irashobora gushonga buhoro kandi byoroshye gukora uturemangingo bigoye kubora.
3. Gupima ubunini
Viscosity nimwe mubintu bikomeye cyane kubiranga HPMC. Ubukonje bwayo mumazi bugira ingaruka kuburemere bwa molekuline no kurwego rwo gusimburwa, kandi mubisanzwe bipimwa na viscometer izunguruka cyangwa capillary viscometer. Uburyo bwihariye nugushonga urugero runaka rwa HPMC mumazi, gutegura igisubizo cyibintu runaka, hanyuma ugapima ubwiza bwumuti. Ukurikije amakuru yibicucu, hashobora kugaragara ko:
Niba agaciro ka viscosity kari hasi cyane, birashobora gusobanura ko uburemere bwa molekile ari buto cyangwa bwangiritse mugihe cyibikorwa;
Niba agaciro ka viscosity ari hejuru cyane, birashobora gusobanura ko uburemere bwa molekile ari bunini cyane cyangwa gusimburwa kutaringaniye.
4. Kumenya neza
Isuku ya HPMC izagira ingaruka ku mikorere yayo. Ibicuruzwa bifite isuku nke akenshi birimo ibisigisigi byinshi cyangwa umwanda. Urubanza rwibanze rushobora gukorwa nuburyo bworoshye bukurikira:
Ikizamini gisigaye ku gutwika: Shira urugero ruto rwa HPMC mu itanura ry'ubushyuhe bwo hejuru hanyuma ubitwike. Ingano isigaye irashobora kwerekana ibiri mumyunyu ngugu na ioni. Ibisigisigi byiza bya HPMC bigomba kuba bito cyane.
Ikizamini cyagaciro pH: Fata urugero rukwiye rwa HPMC hanyuma uyishongeshe mumazi, hanyuma ukoreshe impapuro zipima pH cyangwa metero pH kugirango upime agaciro pH yumuti. Mubihe bisanzwe, igisubizo cyamazi ya HPMC kigomba kuba hafi yo kutabogama. Niba ari acide cyangwa alkaline, umwanda cyangwa ibicuruzwa bishobora kubaho.
5. Imiterere yubushyuhe hamwe nubushyuhe bwumuriro
Mugushyushya icyitegererezo cya HPMC, ituze ryumuriro rirashobora kugaragara. HPMC yujuje ubuziranenge igomba kugira ubushyuhe bwinshi mugihe cyo gushyushya kandi ntigomba kubora cyangwa kunanirwa vuba. Intambwe yoroshye yo gukora ubushyuhe bwikizamini harimo:
Shyushya urugero ruto ku isahani ishyushye hanyuma urebe aho ushonga n'ubushyuhe bwangirika.
Niba icyitegererezo gitangiye kubora cyangwa guhindura ibara ku bushyuhe buke, bivuze ko ubushyuhe bwacyo butameze neza.
6. Kugena ibirimo ubuhehere
Ibirungo byinshi cyane bya HPMC bizagira ingaruka kububiko bwayo no gukora. Ibirungo byayo birashobora kugenwa nuburyo bwuburemere:
Shira icyitegererezo cya HPMC mu ziko hanyuma ukumishe kuri 105 ℃ kugirango uhore ufite uburemere, hanyuma ubare itandukaniro ryibiro mbere na nyuma yo gukama kugirango ubone ibirimo ubuhehere. HPMC yo mu rwego rwo hejuru igomba kuba ifite ubuhehere buke, ubusanzwe bugenzurwa munsi ya 5%.
7. Impamyabumenyi yo gutahura
Urwego rwo gusimbuza imikorere ya hydroxypropoxy ya HPMC igira ingaruka ku mikorere yayo, nko gukomera, ubushyuhe bwa gel, ubukonje, n'ibindi. gukorerwa muri laboratoire. Muri make, HPMC isimbuye nkeya ifite ubushobozi buke kandi irashobora gukora geles zingana mumazi.
8. Ikizamini cya gel
Ubushyuhe bwa gel bwa HPMC nubushyuhe bukora gel mugihe cyo gushyushya. HPMC yo mu rwego rwo hejuru ifite ubushyuhe bwihariye bwa gel, ubusanzwe hagati ya 60 ° C na 90 ° C. Uburyo bwo gupima ubushyuhe bwa gel ni:
Gabanya HPMC mumazi, wongere ubushyuhe buhoro buhoro, kandi witegereze ubushyuhe aho igisubizo gihinduka kiva mumucyo kijya mu gihirahiro, aribwo ubushyuhe bwa gel. Niba ubushyuhe bwa gel butandukanije nurwego rusanzwe, birashobora gusobanura ko imiterere ya molekile cyangwa urwego rwo gusimbuza bitujuje ubuziranenge.
9. Gusuzuma imikorere
Imikorere ya HPMC kubikorwa bitandukanye irashobora kuba itandukanye. Kurugero, mubikorwa byubwubatsi, HPMC ikoreshwa nkibikoresho bigumana amazi kandi bikabyimbye. Amazi yayo agumana imikorere ningaruka zo kubyimba arashobora kugeragezwa hakoreshejwe ubushakashatsi bwa minisiteri. Mu nganda zimiti n’ibiribwa, HPMC ikoreshwa nka firime yahoze cyangwa capsule, kandi ingaruka zayo zo gukora firime hamwe na colloidal birashobora kugeragezwa hakoreshejwe ubushakashatsi.
10. Ibintu binuka kandi bihindagurika
HPMC yo mu rwego rwo hejuru ntigomba kugira umunuko ugaragara. Niba icyitegererezo gifite impumuro nziza cyangwa uburyohe bwamahanga, birashobora gusobanura ko imiti itifuzwa yatangijwe mugihe cyo kuyikora cyangwa ko irimo ibintu bihindagurika cyane. Byongeye kandi, HPMC yo mu rwego rwo hejuru ntigomba kubyara imyuka itera ubushyuhe bwinshi.
Ubwiza bwa HPMC bushobora kugenzurwa nigeragezwa ryoroshye ryumubiri nko kugaragara, gukomera no gupima ibishishwa, cyangwa hakoreshejwe imiti nko gupima ubuziranenge no gupima ubushyuhe. Binyuze muri ubu buryo, urubanza rwibanze rushobora gufatwa ku bwiza bwa HPMC, bityo bigatuma imikorere ihamye mu bikorwa bifatika.
Igihe cyo kohereza: Nzeri-25-2024