Nigute hypromellose ikorwa?

Hypromellose, izwi kandi nka hydroxypropyl methylcellulose (HPMC), ni polymer semisintetike polymer ikomoka kuri selile, polisikaride isanzwe iboneka mu nkuta z’ibimera. Umusaruro wa hypromellose urimo intambwe nyinshi, zirimo etherification no kwezwa. Dore incamake yukuntu hypromellose ikorwa:

1. Isoko rya Cellulose: Inzira itangirana no gushakisha selile, ishobora kuboneka mumasoko atandukanye y'ibimera nk'ibiti by'ibiti, fibre y'ipamba, cyangwa ibindi bimera bya fibrous. Cellulose isanzwe ikurwa muri aya masoko ikoresheje uburyo bwa chimique na mashini kugirango ibone ibikoresho bya selile.
2. Etherification: Cellulose isukuye ikora inzira yo guhindura imiti yitwa etherification, aho hydroxypropyl na methyl zinjizwa mumugongo wa selile. Ihinduka ryagerwaho mugukora selile hamwe na oxyde ya propylene (kumenyekanisha amatsinda ya hydroxypropyl) na methyl chloride (kumenyekanisha amatsinda ya methyl) mugihe cyagenwe.
3. Isuku: Nyuma ya etherification, ibicuruzwa bivamo bigenda bisukurwa kugirango bikureho umwanda nibicuruzwa biva mubitekerezo. Ibi birashobora gukaraba, gushungura, nubundi buryo bwo gutandukana kugirango ubone ibicuruzwa byiza bya hypromellose.
4. Kuma no gusya: hypromellose isukuye noneho yumishwa kugirango ikureho ubuhehere burenze hanyuma igasya ifu nziza cyangwa granules. Ingano yubunini na morphologie yifu ya hypromellose irashobora kugenzurwa kugirango ihuze ibisabwa byihariye mubikorwa bitandukanye.
5. Kugenzura ubuziranenge: Mubikorwa byose byo gukora, ingamba zo kugenzura ubuziranenge zishyirwa mubikorwa kugirango harebwe ubuziranenge, ubudahwema, n'imikorere y'ibicuruzwa bya hypromellose. Ibi birimo kwipimisha ibipimo nkuburemere bwa molekuline, viscosity, solubile, nibindi bintu bifatika na chimique.
6. Gupakira no gukwirakwiza: Igicuruzwa cya hypromellose kimaze kuba cyujuje ubuziranenge, gipakirwa mu bikoresho byabigenewe kandi kigabanywa mu nganda zitandukanye kugira ngo gikoreshwe mu bya farumasi, ibikomoka ku biribwa, kwisiga, n'ibindi bikorwa.

Muri rusange, umusaruro wa hypromellose urimo urukurikirane rwimiti igenzurwa hamwe nintambwe yo kweza ikoreshwa kuri selile, bikavamo polymer zitandukanye kandi zikoreshwa cyane hamwe nibikorwa bitandukanye mubikorwa bitandukanye.