Hydroxypropylmethylcellulose (HPMC) ni uruganda rwahindutse ibikoresho fatizo mu nganda nyinshi kubera imiterere myinshi. Bikunze gukoreshwa nk'inyongeramusaruro, kubyimbye mu kwisiga, ndetse nibikoresho byubuvuzi mumiti myinshi. Umutungo wihariye wa HPMC ni imyitwarire ya thixotropique, ituma ihindura ibishishwa hamwe nibintu bitemba mubihe bimwe. Mubyongeyeho, byombi-viscosity-na-viscosity HPMC bifite uyu mutungo, byerekana thixotropy ndetse no munsi yubushyuhe bwa gel.
Thixotropy ibaho muri HPMC mugihe igisubizo kibaye icyogosha mugihe igitutu gishyizwe cyangwa kivanze, bigatuma kugabanuka kwijimye. Iyi myitwarire irashobora kandi guhinduka; iyo imihangayiko ikuweho kandi igisubizo gisigaye kuruhuka, viscosity isubira buhoro buhoro murwego rwo hejuru. Uyu mutungo udasanzwe utuma HPMC igizwe ningirakamaro mu nganda nyinshi kuko itanga uburyo bworoshye bwo kuyikoresha no kuyitunganya byoroshye.
Nka hydrocolloide idasanzwe, HPMC yabyimbye mumazi ikora gel. Urwego rwo kubyimba no guterwa biterwa nuburemere bwa molekuline hamwe nubunini bwa polymer, pH nubushyuhe bwumuti. Ubukonje bwinshi HPMC mubusanzwe ifite uburemere buke bwa molekuline kandi itanga gel yo hejuru cyane, mugihe ubukonje buke HPMC ifite uburemere buke bwa molekile kandi ikabyara gele nkeya. Nubwo, nubwo itandukaniro ryimikorere, ubwoko bwombi bwa HPMCs bwerekana thixotropy kubera impinduka zimiterere zibaho kurwego rwa molekile.
Imyitwarire ya thixotropique ya HPMC nigisubizo cyo guhuza iminyururu ya polymer kubera guhangayika. Iyo impagarara zogosha zashyizwe kuri HPMC, iminyururu ya polymer ihuza icyerekezo cyimyitwarire ikoreshwa, bikaviramo gusenya imiterere yibice bitatu byurusobe rwabayeho mugihe nta guhangayika. Guhagarika urusobe bivamo kugabanuka kwikemurwa ryibisubizo. Iyo imihangayiko ikuweho, iminyururu ya polymer yongeye gutondekanya icyerekezo cyayo cyambere, kubaka urusobe no kugarura ubwiza.
HPMC irerekana kandi thixotropy munsi yubushyuhe bwa gelling. Ubushyuhe bwa gel nubushyuhe bwa polymer iminyururu ihuza ibice kugirango ibe urusobe rwibice bitatu, rukora gel. Biterwa no kwibanda, uburemere bwa molekuline na pH yumuti wa polymer. Gele yavuyemo ifite ubukonje bwinshi kandi ntabwo ihinduka vuba mukibazo. Nyamara, munsi yubushyuhe bwa gelation, igisubizo cya HPMC cyakomeje kuba amazi, ariko kiracyerekana imyitwarire ya thixotropique bitewe nuko hariho imiterere y'urusobe igice. Umuyoboro wakozwe nibi bice ucika kubera igitutu, bigatuma kugabanuka kwijimye. Iyi myitwarire ningirakamaro mubikorwa byinshi aho ibisubizo bigomba gutemba byoroshye mugihe bikangutse.
HPMC ni imiti itandukanye ifite imiterere yihariye, imwe murimwe ni imyitwarire ya thixotropique. Byombi-viscosity na viscosity HPMCs bifite uyu mutungo, byerekana thixotropy ndetse no munsi yubushyuhe bwa gel. Ibiranga bituma HPMC igizwe ningirakamaro mu nganda nyinshi zisaba ibisubizo bikemura ibibazo byoroshye kugirango byemerwe neza. Nuburyo butandukanye mumitungo iri hagati yubukonje bwinshi nubukonje buke HPMCs, imyitwarire yabo ya thixotropique ibaho kubera guhuza no guhungabanya imiterere yibice bigize urusobe. Bitewe nimiterere yihariye, abashakashatsi bahora bashakisha uburyo butandukanye bwa HPMC, bizeye gukora ibicuruzwa bishya no gutanga ibisubizo byiza kubakoresha ku isi.
Igihe cyo kohereza: Kanama-23-2023