HPMC ifite ubushyuhe bwihariye cyangwa pH isabwa kugirango ishonga mumazi?

Hydroxypropyl Methylcellulose (HPMC) ni inkomoko ya selile ikunze gukoreshwa hamwe nibisabwa byinshi, nk'ubuvuzi, ibiryo, ibikoresho byo kubaka no kwisiga. HPMC ni ionic, igice-synthique, inert polymer ifite amazi meza cyane, kubyimba, gufatira hamwe no gukora firime.

Imiterere n'imiterere ya HPMC

HPMC ni selile yahinduwe ikorwa na selile ikora methyl chloride na oxyde ya propylene. Imiterere ya molekuline ikubiyemo methyl na hydroxypropyl insimburangingo, zitanga HPMC ibintu byihariye byumubiri nubumara, nkibishobora gukemuka neza, kurinda colloid hamwe no gukora firime. HPMC irashobora kugabanywamo ibice byinshi ukurikije insimburangingo zitandukanye, kandi buri cyerekezo kigira imbaraga zitandukanye kandi kigakoreshwa mumazi.

Gukemura HPMC mumazi

Uburyo bwo gusesa
HPMC ikorana na molekile y'amazi ikoresheje imigozi ya hydrogen kugirango ikemuke. Uburyo bwo gusesa burimo molekile zamazi zinjira buhoro buhoro hagati yiminyururu ya molekile ya HPMC, isenya ubumwe bwayo, kuburyo iminyururu ya polymer ikwirakwira mumazi kugirango bibe igisubizo kimwe. Ubushobozi bwa HPMC bufitanye isano cyane nuburemere bwa molekuline, ubwoko bwinsimburangingo hamwe nurwego rwo gusimbuza (DS). Mubisanzwe, urwego rwo hejuru rwo gusimbuza insimburangingo, niko gukomera kwa HPMC mumazi.

Ingaruka yubushyuhe kuri solubile
Ubushyuhe nikimwe mubintu byingenzi bigira ingaruka kuri HPMC. Ubushobozi bwa HPMC mumazi bwerekana ibintu bitandukanye uko ubushyuhe buhinduka:

Ubushyuhe bwo kugabanuka: HPMC iragoye gushonga mumazi akonje (muri rusange munsi ya 40 ° C), ariko irashobora gushonga vuba iyo ishyushye kuri 60 ° C cyangwa irenga. Kuri HPMC ifite ubukonje buke, ubushyuhe bwamazi bugera kuri 60 ° C mubusanzwe ubushyuhe bwiza bwo gushonga. Kubireba cyane HPMC, ubushyuhe bwiza bwo gushonga burashobora kuba hejuru ya 80 ° C.

Gelation mugihe cyo gukonjesha: Iyo igisubizo cya HPMC gishyushye mubushyuhe runaka (mubisanzwe 60-80 ° C) mugihe cyo kumeneka hanyuma kigakonja buhoro, hazashyirwaho gel yumuriro. Iyi gel yumuriro ihinduka neza nyuma yo gukonjesha ubushyuhe bwicyumba kandi irashobora gusubizwa mumazi akonje. Iyi phenomenon ifite akamaro kanini mugutegura ibisubizo bya HPMC kubikorwa runaka (nkibiyobyabwenge bikomeza-kurekura capsules).

Gukuraho neza: Mubisanzwe, ubushyuhe bwo hejuru burashobora kwihutisha inzira yo gusesa HPMC. Nyamara, hejuru cyane ubushyuhe bushobora no gutuma polymer yangirika cyangwa kugabanuka kwijimye. Kubwibyo, mubikorwa nyabyo, ubushyuhe bukwiye bwo guseswa bugomba gutoranywa nkuko bikenewe kugirango wirinde kwangirika bitari ngombwa no guhindura imitungo.

Ingaruka ya pH kubishobora
Nka polymer itari ionic, gukomera kwa HPMC mumazi ntabwo bigira ingaruka kumpamvu ya pH yumuti. Nyamara, imiterere ya pH ikabije (nkibidukikije bikomeye bya acide cyangwa alkaline) irashobora kugira ingaruka kubiranga HPMC:

Imiterere ya acide: Mugihe gikomeye cya acide (pH <3), imiyoboro imwe ya chimique ya HPMC (nka ether bond) irashobora gusenywa nuburyo bwa acide, bityo bikagira ingaruka kumashanyarazi no gutatana. Nyamara, muri rusange intege nke za aside (pH 3-6), HPMC irashobora gushonga neza. Imiterere ya alkaline: Mubihe bikomeye bya alkaline (pH> 11), HPMC irashobora kwangirika, ubusanzwe biterwa na hydrolysis reaction ya hydroxypropyl. Mugihe cya alkaline idakomeye (pH 7-9), imbaraga za HPMC ntizigaragara cyane.

Uburyo bwo gusesa HPMC

Kugirango ushireho HPMC neza, uburyo bukurikira bukoreshwa:

Uburyo bwo gukwirakwiza amazi akonje: Ongeraho buhoro buhoro ifu ya HPMC mumazi akonje mugihe ukurura kugirango uyatatanye. Ubu buryo bushobora kubuza HPMC guhurira mu mazi mu buryo butaziguye, kandi igisubizo kigakora urwego rukingira. Noneho, shyushya buhoro buhoro kugeza kuri 60-80 ° C kugirango ushonga burundu. Ubu buryo bukwiranye no gusesa HPMC nyinshi.

Uburyo bwo gukwirakwiza amazi ashyushye: Ongeramo HPMC mumazi ashyushye hanyuma ubyuke vuba kugirango bishonge vuba mubushyuhe bwinshi. Ubu buryo burakwiriye cyane-HPMC, ariko hakwiye kwitabwaho kugenzura ubushyuhe kugirango wirinde kwangirika.

Uburyo bwo kubanza gukemura igisubizo: Ubwa mbere, HPMC ishonga mumashanyarazi kama (nka Ethanol), hanyuma amazi akongerwaho buhoro buhoro kugirango ahindurwe igisubizo cyamazi. Ubu buryo bukwiranye nibisabwa bidasanzwe hamwe nibisabwa cyane.

Imyitozo yo gusesa mubikorwa bifatika
Mubikorwa bifatika, inzira yo gusesa HPMC igomba gutezimbere ukurikije imikoreshereze yihariye. Kurugero, murwego rwa farumasi, mubisanzwe birakenewe gushiraho igisubizo gihamye kandi gihamye cya colloidal, kandi hagomba gukurikiranwa cyane ubushyuhe na pH kugirango habeho ubukonje nibikorwa byibinyabuzima byumuti. Mu bikoresho byubaka, gukomera kwa HPMC bigira ingaruka kumiterere ya firime nimbaraga zo kwikuramo, bityo uburyo bwiza bwo gusesa bugomba gutoranywa bujyanye nibidukikije byihariye.

Ubushobozi bwa HPMC mumazi bugira ingaruka kubintu byinshi, cyane cyane ubushyuhe na pH. Muri rusange, HPMC ishonga vuba ku bushyuhe bwo hejuru (60-80 ° C), ariko irashobora gutesha agaciro cyangwa guhinduka gake mugihe cya pH ikabije. Kubwibyo, mubikorwa bifatika, birakenewe guhitamo ubushyuhe bukwiye hamwe nubunini bwa pH ukurikije imikoreshereze yihariye n’ibidukikije bya HPMC kugirango ibashe gukemuka neza no gukora.