Hydroxylopyolin (HPMC) ni polymer ikoreshwa cyane mu nganda zimiti kandi ni formulaire yingenzi. Ikoreshwa cyane cyane nk'ifata muri dosiye ihamye (nka tableti, capsules, na selile), viscosity yongerewe imbaraga no kubora.
Mugutegura ibiyobyabwenge, gusesa ibintu bikora nibyingenzi kugirango bikurwe kandi bitange ingaruka zo kuvura. Ariko, gusesa ibintu bikora birashobora kubangamirwa na formula. Niyo mpamvu, ni ngombwa gusobanukirwa imyitwarire yo gushonga ya HPMC mumata yibiyobyabwenge kuko bigira ingaruka kumikorere yubwoko bwa dosiye.
Uburyo bwo gusesa HPMC
Farumasi yo muri Amerika (USP) yashyizeho uburyo bwo gupima HPMC. Ubu buryo busanzwe bukubiyemo gukoresha ibikoresho bishonga, bigereranya kandi bipima ubukana bwubwoko bwa dosiye muburyo bwo gukemura. Ikizamini kirimo gushyira dosiye mugiseke cyangwa padi, kandi igitebo cyangwa padi bizunguruka mubintu birimo uburyo bwashonze.
Uburyo bwo gukemura ibibazo bugomba gutoranywa ukurikije ibiteganijwe gukoreshwa kwa dosiye (nka gastric cyangwa amara gushonga). Uburyo busanzwe bwo gukemura ibibazo bya HPMC burimo amazi, igisubizo cya fosifate hamwe n umutobe wigifu wa gastrica (SGF) cyangwa amazi yo mu nda asa (SIF).
Kugirango tumenye neza kandi bisubirwemo, ibipimo byikizamini bigomba kuba bisanzwe, nkumuvuduko wo kuzunguruka, ubushyuhe, no gushonga ingano yo hagati hamwe nigihe cyo gutoranya. Noneho koresha uburyo bukwiye bwo gusesengura kugirango usesengure igisubizo cyicyitegererezo cyabonetse mugihe gitandukanye kugirango umenye umubare w'iseswa rya HPMC.
Ingamba zo gukumira Iyo ukora ibizamini bya HPMC
1. Guhitamo uburyo bukwiye bwo gushonga: Guhitamo uburyo bwo gushonga bushingiye kumikoreshereze iteganijwe yo gukoresha dosiye. Guhitamo uburyo bukwiye bwo gusesa ni ngombwa cyane kuko bizagira ingaruka kumyitwarire ya HPMC.
2. Kugenzura neza uburyo bwo gukemura: Kugenzura uburyo bwo gukemura kugirango harebwe ko bikwiye kandi ni ngombwa kubahiriza ibisabwa n’ikigo gishinzwe kugenzura. Kugenzura bigomba kuba bikubiyemo imbaraga no gusubiramo ibipimo.
3. Ibipimo ngenderwaho byikizamini: Ibipimo byikizamini, nkumuvuduko wo kuzunguruka, ubushyuhe, nubunini buciriritse bwashonze bigira ingaruka kubisubizo byo gusesa ibizamini. Kubwibyo, ibipimo bigomba kuba byemewe kugirango bigaragare kandi bisesengure neza.
4. Icyitegererezo: Gutoranya witonze ni ngombwa kugirango ubone ibyitegererezo biva muburyo bwo gushonga. Witondere igihe hamwe nicyitegererezo kugirango urebe ko icyitegererezo cyegeranijwe mugihe kimwe.
5. Uburyo bwo gusesengura: Hitamo uburyo bwo gusesengura kugirango bugenzurwe bugomba kugenzurwa, kandi bugomba kugira ibyiyumvo bikwiye, guhitamo no kumenya ukuri.
Muri make, ikizamini cyo gusesa HPMC nigikoresho cyingenzi mugutezimbere ibiyobyabwenge hamwe nibiyobyabwenge. Laboratoire yo kugenzura ubuziranenge ikorwa buri gihe kugirango irekure neza ibintu bikora, kandi ibiyobyabwenge bifite umutekano kandi byiza. Ikosa muburyo bukwiye bwo kwipimisha rishobora gutera kutumvikana no kuvuga ibinyoma ku mikorere yibiyobyabwenge. Niyo mpamvu, ni ngombwa gukurikiza ibipimo n'ingamba zo gukumira mugihe cyo guseswa.
Igihe cyo kohereza: Jun-29-2023