Izina ry'igishinwa rya HPMC ni hydroxypropyl methylcellulose. Ntabwo ari ionic kandi akenshi ikoreshwa nkibikoresho bigumana amazi muri minisiteri ivanze. Nibikoresho bikoreshwa cyane kubika amazi muri minisiteri.
Igikorwa cyo gukora HPMC ahanini ni polisikaride ishingiye kuri ether ikorwa na alkalisation na etherification ya fibre ya pamba (murugo). Ntabwo yishyuza ubwayo, ntabwo ikora hamwe na ion zashizwe mubikoresho bya gell, kandi ifite imikorere ihamye. Igiciro nacyo kiri munsi yubundi bwoko bwa selile ethers, bityo ikoreshwa cyane mumashanyarazi avanze.
Imikorere ya hydroxypropyl methylcellulose: Irashobora kubyimba minisiteri ivanze vuba kugirango igire ububobere buke kandi ikumire amacakubiri. . .
Iyo hejuru ya hydroxypropyl methylcellulose ether, nubushobozi bwo gufata amazi neza. Viscosity nikintu cyingenzi cyimikorere ya HPMC. Kugeza ubu, abakora HPMC batandukanye bakoresha uburyo nibikoresho bitandukanye kugirango bapime ubwiza bwa HPMC. Uburyo nyamukuru ni HaakeRotovisko, Hoppler, Ubbelohde na Brookfield.
Kubicuruzwa bimwe, ibisubizo bya viscosity byapimwe nuburyo butandukanye biratandukanye cyane, ndetse bimwe byikubye kabiri itandukaniro. Kubwibyo, mugihe ugereranije ibishishwa, bigomba gukorwa hagati yuburyo bumwe bwo gupima, harimo ubushyuhe, rotor, nibindi. Nyuma yuko ibice binini bya selile ya selile ihuye namazi, ubuso burahita bushonga hanyuma bugakora jel yo gupfunyika ibikoresho kugirango birinde molekile zamazi gukomeza kwinjira. Rimwe na rimwe, ntishobora gutandukana kimwe no gushonga nubwo nyuma yigihe kirekire ikurura, igakora igisubizo cyijimye cyangwa igiterane. Ifite cyane cyane kubika amazi ya selile ya selile, kandi gukomera ni kimwe mubintu byo guhitamo selile.
Ubwiza nabwo ni indangagaciro yingenzi ya methyl selulose ether. MC ikoreshwa mu ifu yumye isabwa kuba ifu, irimo amazi make, kandi ubwiza nabwo busaba 20% ~ 60% yubunini buke butarenze 63um. Ubwiza bugira ingaruka kuri hydroxypropyl methylcellulose ether. Ubusanzwe MC isanzwe ni granular, kandi biroroshye gushonga mumazi nta agglomeration, ariko igipimo cyo kuyasesa kiratinda cyane, ntabwo rero gikwiriye gukoreshwa mumashanyarazi yumye.
Mu ifu yumye yumye, MC ikwirakwizwa mubikoresho bya sima nka agregate, kuzuza neza na sima, kandi ifu nziza ihagije irashobora kwirinda methyl selulose ether agglomeration mugihe ivanze namazi. Iyo MC yongewemo namazi yo gushonga agglomerates, biragoye cyane gutatanya no gushonga. Ubwiza bwa MC ntabwo busesagura gusa, ahubwo binagabanya imbaraga zaho za minisiteri. Iyo ifu yumye yumye ishyizwe ahantu hanini, umuvuduko wo gukiza wa pompe yumye yumutaka uzagabanuka cyane, kandi ibice bizagaragara kubera ibihe bitandukanye byo gukira. Kuri minisiteri yatewe hamwe nubwubatsi bwa mashini, ibisabwa kubwiza ni byinshi kubera igihe gito cyo kuvanga. Muri rusange, uko ubukonje buri hejuru, ningaruka nziza yo gufata amazi. Nyamara, uko ubukonje buringaniye hamwe nuburemere bwa molekile ya MC, kugabanuka gukwiranye kwayo bizagira ingaruka mbi kumbaraga no mubikorwa bya minisiteri.
Iyo hejuru yubukonje, niko bigaragara ingaruka zo kubyimba kuri minisiteri, ariko ntabwo ihwanye neza. Iyo hejuru yubusembwa, niko amabuye atose azarushaho kuba meza, ni ukuvuga mugihe cyubwubatsi, bigaragarira nko kwizirika kuri scraper no gufatira hejuru kuri substrate. Ariko ntabwo ari byiza kongera imbaraga zimiterere ya minisiteri yonyine. Nukuvuga, mugihe cyo kubaka, imikorere irwanya sag ntabwo igaragara. Ibinyuranye na byo, bimwe mu biciriritse kandi bito ariko byahinduwe na methyl selulose ethers bifite imikorere myiza mugutezimbere imiterere yimiterere ya minisiteri.
Kugumana amazi ya HPMC bifitanye isano nubushyuhe bwakoreshejwe, kandi kubika amazi ya methyl selulose ether bigabanuka hamwe no kwiyongera kwubushyuhe. Nyamara, mubikorwa bifatika, ifu yumye yumye ikoreshwa mubutaka bushyushye mubushyuhe bwinshi (hejuru ya dogere 40) ahantu henshi, nko kurukuta rwinyuma rushyira munsi yizuba mugihe cyizuba, akenshi byihutisha Gukiza sima no gukomera kwa ifu yumye. Kugabanuka kw'igipimo cyo gufata amazi biganisha ku kumva ko gukora ndetse no kurwanya ibice bigira ingaruka, kandi ni ngombwa cyane cyane kugabanya ingaruka ziterwa nubushyuhe muri iki kibazo.
Ni muri urwo rwego, methyl hydroxyethyl selulose ether inyongeramusaruro zifatwa nkiziri ku isonga mu iterambere ry’ikoranabuhanga. Nubwo ingano ya methyl hydroxyethyl selulose yiyongereye (formula yo mu cyi), gukora no kurwanya ibice ntibishobora guhaza ibikenewe gukoreshwa. Binyuze mu buvuzi budasanzwe kuri MC, nko kongera urugero rwa etherification, nibindi, ingaruka zo gufata amazi zirashobora kugumana ubushyuhe bwinshi, kugirango zishobore gutanga imikorere myiza mubihe bibi.
Igipimo cya HPMC ntigikwiye kuba kinini, bitabaye ibyo bizongera amazi ya minisiteri, bizakomeza kuri trowel, kandi igihe cyo kugena kizaba kirekire cyane, kizagira ingaruka kumyubakire. Ibicuruzwa bitandukanye bya minisiteri bifashisha HPMC hamwe nubucucike butandukanye, kandi ntukoreshe cyane-HPMC kubwubusa. Kubwibyo, nubwo hydroxypropyl methylcellulose ibicuruzwa ari byiza, barashimwa iyo bikoreshejwe neza. Guhitamo neza HPMC ninshingano yibanze yabakozi ba laboratoire. Kugeza ubu, abadandaza benshi batitonda barimo guhuza HPMC, kandi ubuziranenge ni bubi. Mugihe uhisemo selile runaka, laboratoire igomba gukora akazi keza mubigeragezo kugirango igenzure neza ibicuruzwa bya minisiteri, kandi ntukabe umururumba uhendutse kandi utera igihombo kidakenewe.
Igihe cyo kohereza: Gicurasi-04-2023