Hydroxypropyl methylcellulose (HPMC)ni selile yingenzi ya selile hamwe nibikorwa byinshi, cyane cyane mubikorwa byubwubatsi, ubuvuzi, ibiryo, nibindi. Ukurikije uburyo butandukanye bwo gutunganya, HPMC irashobora kugabanywa muburyo bwo kuvura no kutavurwa.
1. Itandukaniro mubikorwa byumusaruro
HPMC itavuwe
HPMC itavuwe ntishobora kuvurwa hejuru yubutaka mugihe cyibikorwa, bityo hydrophilicity hamwe na solubile yayo bigumaho. Ubu bwoko bwa HPMC burabyimba vuba kandi butangira gushonga nyuma yo guhura namazi, byerekana ubwiyongere bwihuse bwijimye.
Ububiko bwa HPMC
Ubuso buvuwe na HPMC buzaba bufite ubundi buryo bwo gutwikira nyuma yo gukora. Ibikoresho bisanzwe byo kuvura ni acide acike cyangwa ibindi bintu bidasanzwe. Binyuze muri ubu buvuzi, hazakorwa firime hydrophobique hejuru yubutaka bwa HPMC. Ubu buvuzi butinda inzira yo gusesa, kandi mubisanzwe birakenewe kugirango ushireho iseswa ukoresheje umwe.
2. Itandukaniro muburyo bwo gukemura
Iseswa riranga HPMC itavuwe
HPMC itavuwe izatangira gushonga ako kanya nyuma yo guhura namazi, akwiranye na ssenariyo hamwe nibisabwa cyane kugirango umuvuduko ushonga. Ariko, kubera ko iseswa ryihuse rishobora gukora agglomerates, umuvuduko wo kugaburira hamwe no gukurura uburinganire ugomba kugenzurwa neza.
Ibiranga iseswa biranga HPMC
Igifuniko hejuru yubutaka bwa HPMC butunganijwe bifata igihe cyo gushonga cyangwa gusenya, bityo igihe cyo gusesa ni kirekire, mubisanzwe iminota mike kugeza kuminota irenga icumi. Igishushanyo kirinda gushiraho agglomerates kandi irakwiriye cyane cyane kubintu bisaba ubunini bunini bwihuta cyangwa ubwiza bwamazi mugihe cyo kongeramo.
3. Itandukaniro mubiranga ubwiza
HPMC itunganijwe neza ntishobora guhita irekura ubwiza mbere yo guseswa, mugihe HPMC itavuwe izahita yongera ubwiza bwa sisitemu. Kubwibyo, mugihe aho ubukonje bugomba guhinduka buhoro buhoro cyangwa inzira ikagenzurwa, ubwoko bwavuwe hejuru bufite ibyiza byinshi.
4. Itandukaniro mubihe byakurikizwa
HPMC itavuwe neza
Birakwiriye kumashusho isaba guseswa byihuse ningaruka zihuse, nkibikoresho bya capsule byihutirwa byo murwego rwa farumasi cyangwa kubyibuha byihuse mubiribwa.
Irakora kandi neza mubushakashatsi bwa laboratoire cyangwa umusaruro muto hamwe no kugenzura neza ibiryo bikurikirana.
Ububiko bwa HPMC
Ikoreshwa cyane mubikorwa byubwubatsi, kurugero, muri minisiteri yumye, gufatira tile, gutwikira nibindi bicuruzwa. Biroroshye gutatanya kandi ntabwo ikora agglomerates, ikwiranye cyane nuburyo bwubatswe bwimashini.
Irakoreshwa kandi mubikorwa bimwe na bimwe bya farumasi bisaba kurekurwa bihoraho cyangwa inyongeramusaruro zigenzura igipimo cyo guseswa.
5. Ibiciro nububiko butandukanye
Igiciro cyumusaruro wubutaka bwa HPMC burenze gato ugereranije nubuvuzi butavuwe, bugaragarira mubitandukaniro ryibiciro byisoko. Byongeye kandi, ubwoko bwavuwe hejuru bufite ubwirinzi kandi bufite ibisabwa bike kubushuhe nubushuhe bwibidukikije, mugihe ubwoko butavuwe ari hygroscopique kandi busaba uburyo bukomeye bwo kubika.
6. Ishingiro ryo gutoranya
Mugihe uhisemo HPMC, abakoresha bakeneye gusuzuma ingingo zikurikira ukurikije ibikenewe:
Igipimo cyo gusesa ni ngombwa?
Ibisabwa kugirango umuvuduko wubwiyongere bwubwiyongere.
Niba uburyo bwo kugaburira no kuvanga byoroshye gukora agglomerates.
Inganda zinganda zisabwa intego hamwe nibikorwa byanyuma bisabwa kubicuruzwa.
Ubuso buvuwe kandi butari hejuru-buvuweHPMCbafite imiterere yabo. Iyambere itezimbere ubworoherane bwo gukoresha no gutezimbere imikorere ihindura imyitwarire yo gusesa, kandi irakwiriye kubyara inganda nini; iyanyuma igumana umuvuduko mwinshi kandi irakwiriye cyane mubikorwa byiza bya chimique bisaba umuvuduko mwinshi. Guhitamo ubwoko bugomba guhuzwa nuburyo bwihariye bwo gusaba, imiterere yimikorere ningengo yimari.
Igihe cyo kohereza: Ugushyingo-20-2024