Kumenya Ubuziranenge bwa HPMC Hydroxypropyl Methyl Cellulose

Hydroxypropyl methylcellulose, ikunze kwitwa HPMC, ni imiti ikoreshwa cyane mu miti kandi yongera ibiryo. Bitewe nubushobozi buhebuje, guhuza imbaraga hamwe nuburyo bwo gukora firime, yakoreshejwe cyane mubikorwa bya farumasi. HPMC nayo isanzwe ikoreshwa mubikorwa byibiribwa nkibibyimbye, emulifier na stabilisateur. Isuku ya HPMC ifite akamaro kanini mu nganda zimiti n’ibiribwa kuko igira ingaruka ku mikorere n’umutekano w’ibicuruzwa. Iyi ngingo izaganira ku kumenya isuku ya HPMC nuburyo bwayo.

HPMCs ni iki?

Hydroxypropylmethylcellulose (HPMC) ni selile ya selile ikomoka kuri methylcellulose. Uburemere bwa molekuline ni 10,000 kugeza 1.000.000 Daltons, kandi ni ifu yera cyangwa yera-yera, idafite impumuro nziza kandi itaryoshye. HPMC irashobora gushonga byoroshye mumazi, kandi ikanashonga mumashanyarazi amwe nka Ethanol, butanol, na chloroform. Ifite ibintu bimwe byihariye nko kubika amazi, kubyimba no guhuza ubushobozi, bigatuma biba byiza mubikorwa bya farumasi nibiribwa.

Kumenya ubuziranenge bwa HPMC

Isuku ya HPMC iterwa nimpamvu nyinshi nkurwego rwo gusimbuza (DS), ibirimo ubushuhe nibirimo ivu. DS yerekana umubare wamatsinda ya hydroxyl yasimbujwe nitsinda rya hydroxypropyl muri molekile ya selile. Urwego rwo hejuru rwo gusimbuza rwongera imbaraga za HPMC kandi rutezimbere ubushobozi bwo gukora film. Ibinyuranye, urwego ruto rwo gusimbuza byavamo kugabanuka gukemuka hamwe nimiterere mibi ya firime.

HPMC Uburyo bwo Kugena Isuku

Hariho uburyo bwinshi bwo kumenya ubuziranenge bwa HPMC, harimo titre-fatizo ya titre, isesengura ryibanze, chromatografiya ikora cyane (HPLC), hamwe na infragre spekitroscopi (IR). Dore ibisobanuro kuri buri buryo:

acide-ishingiro

Uburyo bushingiye kubikorwa byo kutabogama hagati ya acide nitsinda ryibanze muri HPMC. Ubwa mbere, HPMC yasheshwe mumashanyarazi kandi ingano izwi ya acide cyangwa igisubizo fatizo cyibintu bizwi byongeweho. Titration yakozwe kugeza pH igeze aho itabogamye. Uhereye ku mubare wa aside cyangwa base yakoreshejwe, urwego rwo gusimburwa rushobora kubarwa.

Isesengura ryibanze

Isesengura ryibanze ripima ijanisha rya buri kintu kiboneka murugero, harimo karubone, hydrogen, na ogisijeni. Urwego rwo gusimbuza rushobora kubarwa uhereye ku mubare wa buri kintu kiboneka muri sample ya HPMC.

Amazi meza ya Chromatografiya (HPLC)

HPLC nubuhanga bukoreshwa cyane bwo gusesengura butandukanya ibice bivanze bishingiye ku mikoranire yabo nicyiciro gihagaze na mobile. Muri HPMC, urwego rwo gusimburwa rushobora kubarwa mugupima igipimo cya hydroxypropyl na methyl matsinda murugero.

Infrared Spectroscopy (IR)

Infrared spectroscopy nubuhanga bwo gusesengura bupima kwinjiza cyangwa kwanduza imirasire yimirasire hamwe nicyitegererezo. HPMC ifite impinga zitandukanye zo kwinjiza hydroxyl, methyl na hydroxypropyl, zishobora gukoreshwa kugirango hamenyekane urwego rwo gusimburwa.

Isuku ya HPMC ni ingenzi mu nganda zikora imiti n’ibiribwa, kandi icyemezo cyayo ni ingenzi mu kurinda umutekano n’ibikorwa by’ibicuruzwa byanyuma. Uburyo bwinshi burahari kugirango hamenyekane ubuziranenge bwa HPMC, harimo titre-base titre, isesengura ryibanze, HPLC, na IR. Buri buryo bufite ibyiza byabwo nibibi kandi birashobora gutoranywa ukurikije ibisabwa byihariye bya porogaramu. Kugirango ugumane isuku ya HPMC, igomba kubikwa ahantu humye, hakonje kure yizuba nizindi zanduza.