Hydroxypropyl methylcellulose (HPMC) ni uruganda rukora cyane rukoreshwa cyane mu nganda zitandukanye bitewe n’imiterere yihariye y’imiti n'imiterere.
1. Ibigize imiti:
a. Umugongo wa selile:
HPMC ikomoka kuri selile, bivuze ko ikomoka kuri selile, polyisikaride isanzwe iboneka murukuta rw'utugingo ngengabuzima. Cellulose igizwe no gusubiramo ibice bya β-D-glucose ihujwe na β (1 → 4) glycosidic.
b. Gusimburwa:
Muri HPMC, hydroxyl (-OH) yimitsi yumugongo wa selile isimbuzwa methyl na hydroxypropyl. Uku gusimburwa kubaho binyuze muri etherification reaction. Impamyabumenyi yo gusimbuza (DS) bivuga impuzandengo y'amatsinda ya hydroxyl yasimbujwe buri glucose murwego rwa selile. DS ya methyl na hydroxypropyl matsinda aratandukanye, bigira ingaruka kumikorere ya HPMC.
2. Synthesis:
a. Etherification:
HPMC ikomatanyirizwa hamwe binyuze muri etherification ya selile hamwe na okiside ya propylene na methyl chloride. Inzira ikubiyemo reaction ya selile hamwe na okiside ya propylene kugirango itangize amatsinda ya hydroxypropyl hanyuma hamwe na methyl chloride kugirango tumenye amatsinda ya methyl.
b. Impamyabumenyi yo kugenzura ubundi buryo:
DS ya HPMC irashobora kugenzurwa no guhindura imiterere yubushyuhe nkubushyuhe, igihe cyo kubyitwaramo, hamwe nubushakashatsi bwibanze.
3. Imikorere:
a. Gukemura:
HPMC ibora mumazi hamwe na solge zimwe na zimwe, nka methanol na Ethanol. Nyamara, gukomera kwayo kugabanuka hamwe no kongera uburemere bwa molekile hamwe nurwego rwo gusimburwa.
b. Gushinga firime:
HPMC ikora firime ibonerana, yoroheje iyo ishonga mumazi. Izi firime zifite imbaraga zumukanishi hamwe na barrière.
C. Ubusabane:
Ibisubizo bya HPMC byerekana imyitwarire ya pseudoplastique, bivuze ko ububobere bwabo bugabanuka hamwe no kongera igipimo cyogosha. Ubwiza bwibisubizo bya HPMC biterwa nibintu nko kwibanda, uburemere bwa molekile, hamwe nurwego rwo gusimburwa.
d. Kubika amazi:
Imwe mu miterere yingenzi ya HPMC nubushobozi bwayo bwo kugumana amazi. Uyu mutungo ni ingenzi mubikorwa bitandukanye nkibikoresho byubwubatsi, aho HPMC ikoreshwa nkibikoresho binini kandi bigumana amazi.
e. Kwizirika:
HPMC ikunze gukoreshwa nk'ifata mu nganda zitandukanye bitewe n'ubushobozi ifite bwo guhuza imiyoboro ikomeye na substrate zitandukanye.
4. Gusaba:
a. Inganda zimiti:
Muri farumasi, HPMC ikoreshwa nka binder, agent ya coating firime, igenzura irekura, hamwe na viscosity modifier muburyo bwa tablet.
b. Inganda zubaka:
HPMC yongewe kuri minisiteri ishingiye kuri sima, plaque ishingiye kuri gypsumu hamwe nudukaratasi twa tile kugirango tunoze imikorere, gufata amazi no gufatira hamwe.
C. inganda zibiribwa:
Mu nganda zibiribwa, HPMC ikoreshwa nkibyimbye, stabilisateur na emulisiferi mubicuruzwa nka sosi, imyambarire na ice cream.
d. Ibicuruzwa byita ku muntu:
HPMC ikoreshwa nkibibyimbye, emulifisiyeri nogukora firime mubicuruzwa byita kumuntu nka shampo, amavuta yo kwisiga hamwe na cream.
e. Irangi hamwe n'ibifuniko:
Mu gusiga amarangi no gutwikira, HPMC ikoreshwa mugutezimbere pigment, kugenzura ububobere no gufata amazi.
Hydroxypropylmethylcellulose (HPMC) nuruvange rwinshi rufite uburyo butandukanye bwo gukoresha mubikorwa bitandukanye. Imiterere yihariye ya chimique, synthesis hamwe nibintu bituma iba ikintu cyingenzi muri farumasi, ibikoresho byubaka, ibiryo, ibicuruzwa byita kumuntu hamwe n amarangi / gutwikira. Gusobanukirwa imiterere ya HPMC itanga porogaramu yihariye mubice bitandukanye, bigira uruhare mugukoresha kwinshi nakamaro mubikorwa bigezweho.
Igihe cyo kohereza: Gashyantare-22-2024