Hydroxypropyl methylcellulose (HPMC) ni polymerike ya sintetike ya santimetike ikoreshwa cyane mu nganda nyinshi, cyane cyane mu bya farumasi. HPMC yabaye ingirakamaro mu myiteguro ya farumasi bitewe na biocompatibilité, idafite uburozi hamwe n’imiterere myiza y’umubiri n’imiti.
(1) Ibiranga shingiro byurwego rwa farumasi HPMC
HPMC ni ether ya ionic selulose ether yateguwe nigikorwa cya selile hamwe na oxyde ya propylene na methyl chloride mugihe cya alkaline. Imiterere yihariye yimiti itanga HPMC gukemura neza, kubyimba, gukora firime no kwigana. Ibikurikira nibintu bimwe byingenzi biranga HPMC:
Amazi meza hamwe na pH biterwa: HPMC ishonga mumazi akonje kandi ikora igisubizo kibonerana. Ubukonje bwibisubizo byabwo bujyanye no kwibanda hamwe nuburemere bwa molekuline, kandi bifite ituze rikomeye kuri pH kandi birashobora kuguma bihamye haba mubidukikije ndetse na alkaline.
Imiterere ya Thermogel: HPMC yerekana imiterere yihariye ya thermogel iyo ishyushye. Irashobora gukora gel iyo ishyushye mubushyuhe runaka hanyuma igasubira mumazi nyuma yo gukonja. Uyu mutungo ni ingenzi cyane mubiyobyabwenge bikomeza-kurekura.
Biocompatibilité and non-toxicity: Kubera ko HPMC ikomoka kuri selile kandi ikaba idafite amafaranga kandi ntizongera gukora nibindi bikoresho, ifite biocompatibilité nziza kandi ntizinjira mu mubiri. Nibintu bidafite uburozi.
(2) Gukoresha HPMC mumiti
HPMC ikoreshwa cyane mu nganda zimiti, ikubiyemo imirima myinshi nkimiti yo mu kanwa, iyambere ndetse ninshinge. Icyerekezo cyingenzi cyo gusaba ni ibi bikurikira:
1. Ibikoresho byo gukora firime mubitabo
HPMC ikoreshwa cyane muburyo bwo gutwikira ibinini nkibikoresho byerekana firime. Gufata ibinini ntibishobora kurinda gusa ibiyobyabwenge ingaruka z’ibidukikije, nk’ubushuhe n’umucyo, ariko kandi bitwikira impumuro mbi nuburyohe bwibiyobyabwenge, bityo bikarushaho kubahiriza abarwayi. Filime yakozwe na HPMC ifite imbaraga zo kurwanya amazi nimbaraga, zishobora kongera ubuzima bwibiyobyabwenge.
Muri icyo gihe, HPMC irashobora kandi gukoreshwa nkigice cyingenzi cyibikoresho bigenzurwa-bigasohoka kugirango habeho umusaruro uhoraho-urekura kandi ugenzurwa-kurekura. Imiterere ya gel yumuriro ituma imiti irekurwa mumubiri ku kigero cyagenwe cyo kurekura, bityo bikagera ku ngaruka zo kuvura imiti igihe kirekire. Ibi ni ingenzi cyane mu kuvura indwara zidakira, nk'imiti ndende ikenera abarwayi ba diyabete na hypertension.
2. Nkumukozi uhoraho-kurekura
HPMC ikoreshwa cyane nkumukozi uhoraho-urekura imiti yo gutegura umunwa. Kubera ko ishobora gukora jel mumazi kandi geli igenda ishonga buhoro buhoro uko imiti irekuwe, irashobora kugenzura neza igipimo cyo kurekura ibiyobyabwenge. Iyi porogaramu ni ingenzi cyane mu biyobyabwenge bisaba kurekura ibiyobyabwenge igihe kirekire, nka insuline, antidepressants, nibindi.
Mugihe cya gastrointestinal, geli ya HPMC irashobora kugena igipimo cyo kurekura imiti, ikirinda kurekura vuba imiti mugihe gito, bityo bikagabanya ingaruka mbi kandi bikongerera imbaraga. Uyu mutungo urekuwe urakenewe cyane cyane kuvura imiti isaba kwibanda kumiti itajegajega, nka antibiotike, imiti igabanya ubukana, nibindi.
3. Nkumuhuza
HPMC ikoreshwa kenshi nka binder mugikorwa cyo gukora tablet. Mugushyiramo HPMC ibice byibiyobyabwenge cyangwa ifu, amazi yayo hamwe no gufatira hamwe birashobora kunozwa, bityo bikazamura ingaruka zo kwikuramo imbaraga nimbaraga za tablet. Kutagira uburozi no gutuza kwa HPMC bituma bihuza neza mubinini, granules na capsules.
4. Nkibyimbye na stabilisateur
Mu myiteguro y’amazi, HPMC ikoreshwa cyane nkibyimbye na stabilisateur mumazi atandukanye yo mu kanwa, ibitonyanga byamaso hamwe na cream yibanze. Umubyimba wacyo urashobora kongera ubukana bwibiyobyabwenge byamazi, ukirinda ibiyobyabwenge cyangwa imvura, kandi bikagabanywa kimwe mubigize ibiyobyabwenge. Muri icyo gihe, amavuta yo kwisiga hamwe nubushuhe bwa HPMC bituma bigabanya neza kutoroherwa kwamaso kumatonyanga y amaso no kurinda amaso kurakara hanze.
5. Byakoreshejwe muri capsules
Nka selile ikomoka ku bimera, HPMC ifite biocompatibilité nziza, ikagira ibikoresho byingenzi byo gukora capsules yibihingwa. Ugereranije na capsules ya gelatine gakondo, capsules ya HPMC ifite umutekano muke, cyane cyane mubushyuhe bwinshi nubushyuhe bwinshi, kandi ntibyoroshye guhinduka cyangwa gushonga. Byongeye kandi, capsules ya HPMC ibereye ibikomoka ku bimera n’abarwayi bafite allergique ya gelatine, ikagura uburyo bwo gukoresha imiti ya capsule.
(3) Ibindi biyobyabwenge bya HPMC
Usibye ibiyobyabwenge byavuzwe haruguru, HPMC irashobora no gukoreshwa mubice bimwe byibiyobyabwenge. Kurugero, nyuma yo kubagwa amaso, HPMC ikoreshwa mumatonyanga yijisho nkamavuta yo kugabanya ubushyamirane hejuru yijisho ryijisho kandi bigatera gukira. Byongeye kandi, HPMC irashobora kandi gukoreshwa mumavuta na geles kugirango iteze imbere ibiyobyabwenge no kunoza imikorere yibiyobyabwenge byaho.
Urwego rwa farumasi HPMC igira uruhare runini mugutegura imiti kubera imiterere myiza yumubiri nubumara. Nka farumasi ikora ibintu byinshi, HPMC ntishobora gusa guteza imbere ibiyobyabwenge no kugenzura irekurwa ryibiyobyabwenge, ahubwo inatezimbere uburambe bwo gufata ibiyobyabwenge no kongera abarwayi. Hamwe niterambere ryiterambere rya tekinoroji yimiti, urwego rwo gukoresha HPMC ruzaba rwagutse kandi ruzagira uruhare runini mugutezimbere ibiyobyabwenge.
Igihe cyo kohereza: Nzeri-19-2024