Ibyiza bya HPMC (hydroxypropyl methylcellulose) mu nganda zimiti bigaragarira mubintu byinshi, kandi imiterere yihariye ituma ikoreshwa cyane.
1. Ibintu byiza cyane byo kubyimba no gutondeka
HPMC nigikoresho cyamazi gishonga polymer gifite umubyimba mwiza kandi mwiza. Mu nganda zikora imiti, HPMC irashobora gukoreshwa nkibintu byongera umubyimba kugirango byongere ubwiza nubwiza bwimyiteguro. Ibi ni ingenzi cyane cyane kubitegura amazi (nk'amazi yo mu kanwa n'ibitonyanga), bishobora kunoza imiterere ya rheologiya yibiyobyabwenge kandi bigahuza uburinganire n'ubwuzuzanye.
2. Biocompatibilité
HPMC ifite biocompatibilité nziza na biodegradabilite kandi irakwiriye gukoreshwa munganda zimiti, cyane cyane mugutegura imyunvire ninshinge. Kubera ko ikomoka ku bimera, HPMC ntabwo ari uburozi kandi nta ngaruka mbi ku mubiri w'umuntu, bigabanya ibyago byo gufata nabi imiti.
3. Kugenzura ibintu byo kurekura
HPMC ikoreshwa kenshi mugutegura ibiyobyabwenge-bigenzurwa-bikomeza-kurekura imiti. Imiterere yacyo irashobora kugabanya igipimo cyo kurekura ibiyobyabwenge, kugera kurekura imiti ihoraho, kugabanya inshuro zubuyobozi, no kunoza iyubahirizwa ry’abarwayi. Uyu mutungo ni ingenzi cyane mu kuvura indwara zidakira, nka hypertension na diyabete.
4. Gukemura neza no gushikama
HPMC irashobora gushonga mumazi byoroshye kandi irashobora kuguma ihagaze mubihe bitandukanye bya pH. Ibi bituma ikoreshwa cyane muburyo butandukanye bwo gutegura imiti. Haba muri acide cyangwa alkaline, HPMC irashobora gukomeza imikorere yayo kandi ikemeza ko ibiyobyabwenge bihagaze neza.
5. Kongera bioavailable yibiyobyabwenge
HPMC irashobora kunoza bioavailable yimiti imwe n'imwe, cyane cyane kumiti idashonga. Muguhuza ibiyobyabwenge, HPMC irashobora kunoza kwinjiza ibiyobyabwenge mumubiri no kongera ingaruka zo kuvura. Ibi bifite akamaro kanini mugutezimbere imiti mishya, cyane cyane imiti ya molekile ntoya nibiyobyabwenge.
6. Imiterere ihebuje
Mubikorwa bya farumasi, HPMC irashobora gukoreshwa nkumuhuza mugutegura ibinini na capsules kugirango byongere imbaraga nubukomezi bwimyiteguro. Irashobora kunoza imiti igabanya ubukana, ikemeza uburinganire nuburinganire bwibinini, kandi bikagabanya igipimo cyo gutandukana.
7. Birashoboka cyane
HPMC ihuje nibiyobyabwenge bitandukanye kandi ikoreshwa cyane mumyiteguro itandukanye nka tableti, capsules, ibisubizo byo munwa, inshinge, nibindi. Byongeye kandi, HPMC irashobora kandi gukoreshwa mugutegura emulisiyo, geles nifuro, nibindi, kwerekana. imikorere yayo munganda zimiti.
8. Igiciro gito
Ugereranije nibindi bikoresho bya polymer, HPMC ifite igiciro gito cyumusaruro, kandi imiterere yumubiri na chimique irashobora guhinduka muguhindura urwego rwo gusimbuza amatsinda ya hydroxyl. Kubwibyo, ikoreshwa rya HPMC mu nganda zimiti ntabwo ritezimbere imikorere yibicuruzwa gusa, ahubwo binagabanya igiciro cyumusaruro.
Ikoreshwa ryinshi rya HPMC mu nganda zimiti nigisubizo cyibintu byinshi byiza cyane. Haba mukuzamura ituze na bioavailable yibiyobyabwenge cyangwa mukuzamura imiterere yumubiri wimyiteguro, HPMC yerekanye ibyiza byingenzi. Hamwe niterambere ryikoranabuhanga rya farumasi, ibyifuzo bya HPMC biracyari binini, kandi biteganijwe ko bizagira uruhare runini mugutezimbere no gukora imiti mishya.
Igihe cyo kohereza: Nzeri-26-2024